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Averting inflammation by targeting the cytokine environment.
Journal article

Averting inflammation by targeting the cytokine environment.

  • Kopf M Molecular Biomedicine, Institute of Integrative Biology, ETH Zürich, Wagistrasse 27, 8952 Zürich, Switzerland. Manfred.Kopf@ethz.ch
  • Bachmann MF
  • Marsland BJ
  • 2010-09-03
Published in:
  • Nature reviews. Drug discovery. - 2010
Animals
Chronic Disease
Cytokines
Drug Delivery Systems
Drug Design
Humans
Inflammation
English Cytokines are key instigators and regulators of immune responses and therefore hold great potential as targets for new therapeutic strategies. However, the selection of which cytokines to target, and in particular the identification of which cytokines regulate the rate-limiting steps of disease pathways, is crucial to the success of such strategies. Moreover, balancing the need for ablating pathological inflammatory responses and simultaneously maintaining the ability to control infectious agents is a key consideration. Recent advances in our understanding of cytokine networks, as well as technical progress in blocking cytokines in vivo, are likely to be a source for new drugs that can control chronic inflammatory diseases.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/217074
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