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Journal article

Postreplicative mismatch repair.

  • Jiricny J Institute of Molecular Cancer Research, University of Zurich and ETH Zurich, 8057 Zurich, Switzerland. jiricny@imcr.uzh.ch
  • 2013-04-03
Published in:
  • Cold Spring Harbor perspectives in biology. - 2013
Amino Acid Sequence
Animals
Base Pair Mismatch
DNA
DNA Damage
DNA Mismatch Repair
DNA Repair
Escherichia coli
Escherichia coli Proteins
Humans
Molecular Sequence Data
MutS DNA Mismatch-Binding Protein
Protein Conformation
Recombination, Genetic
Reproducibility of Results
Sequence Homology, Amino Acid
Signal Transduction
English The mismatch repair (MMR) system detects non-Watson-Crick base pairs and strand misalignments arising during DNA replication and mediates their removal by catalyzing excision of the mispair-containing tract of nascent DNA and its error-free resynthesis. In this way, MMR improves the fidelity of replication by several orders of magnitude. It also addresses mispairs and strand misalignments arising during recombination and prevents synapses between nonidentical DNA sequences. Unsurprisingly, MMR malfunction brings about genomic instability that leads to cancer in mammals. But MMR proteins have recently been implicated also in other processes of DNA metabolism, such as DNA damage signaling, antibody diversification, and repair of interstrand cross-links and oxidative DNA damage, in which their functions remain to be elucidated. This article reviews the progress in our understanding of the mechanism of replication error repair made during the past decade.
Language
  • English
Open access status
bronze
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Persistent URL
https://sonar.ch/global/documents/217222
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