The Dynamics of Functional Brain Networks: Integrated Network States during Cognitive Task Performance.
- Shine JM Department of Psychology, Stanford University, Stanford, CA 94305, USA; Neuroscience Research Australia, University of New South Wales, Sydney NSW 2052, Australia. Electronic address: macshine@stanford.edu.
- Bissett PG Department of Psychology, Stanford University, Stanford, CA 94305, USA.
- Bell PT University of Queensland Centre for Clinical Research, University of Queensland, Brisbane QLD 4072, Australia.
- Koyejo O Department of Psychology, Stanford University, Stanford, CA 94305, USA.
- Balsters JH Department of Health Sciences and Technology, Neural Control of Movement Laboratory, ETH Zurich, 8092 Zurich, Switzerland.
- Gorgolewski KJ Department of Psychology, Stanford University, Stanford, CA 94305, USA.
- Moodie CA Department of Psychology, Stanford University, Stanford, CA 94305, USA.
- Poldrack RA Department of Psychology, Stanford University, Stanford, CA 94305, USA.
- 2016-10-04
Published in:
- Neuron. - 2016
Adult
Brain
Brain Mapping
Cognition
Female
Functional Neuroimaging
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Nerve Net
Neural Pathways
Pupil
Task Performance and Analysis
English
Higher brain function relies upon the ability to flexibly integrate information across specialized communities of brain regions; however, it is unclear how this mechanism manifests over time. In this study, we used time-resolved network analysis of fMRI data to demonstrate that the human brain traverses between functional states that maximize either segregation into tight-knit communities or integration across otherwise disparate neural regions. Integrated states enable faster and more accurate performance on a cognitive task, and are associated with dilations in pupil diameter, suggesting that ascending neuromodulatory systems may govern the transition between these alternative modes of brain function. Together, our results confirm a direct link between cognitive performance and the dynamic reorganization of the network structure of the brain.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1016/j.neuron.2016.09.018
- PMID 27693256
- Persistent URL
- https://sonar.ch/global/documents/217577
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