Cartilage tissue engineering for degenerative joint disease.
- Nesic D Institute of Pathology, University of Bern, Murtenstrasse 31, 3010 Bern, Switzerland.
- Whiteside R
- Brittberg M
- Wendt D
- Martin I
- Mainil-Varlet P
- 2006-04-01
Published in:
- Advanced drug delivery reviews. - 2006
Animals
Bioreactors
Cartilage
Cell Transplantation
Humans
Joint Diseases
Osteoarthritis
Physical Stimulation
Tissue Engineering
English
Pain in the joint is often due to cartilage degeneration and represents a serious medical problem affecting people of all ages. Although many, mostly surgical techniques, are currently employed to treat cartilage lesions, none has given satisfactory results in the long term. Recent advances in biology and material science have brought tissue engineering to the forefront of new cartilage repair techniques. The combination of autologous cells, specifically designed scaffolds, bioreactors, mechanical stimulations and growth factors together with the knowledge that underlies the principles of cell biology offers promising avenues for cartilage tissue regeneration. The present review explores basic biology mechanisms for cartilage reconstruction and summarizes the advances in the tissue engineering approaches. Furthermore, the limits of the new methods and their potential application in the osteoarthritic conditions are discussed.
- Language
-
- English
- Open access status
- green
- Identifiers
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- DOI 10.1016/j.addr.2006.01.012
- PMID 16574268
- Persistent URL
- https://sonar.ch/global/documents/218650
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