Journal article
The multifaceted mismatch-repair system.
- Jiricny J Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. jiricny@imcr.unizh.ch
- 2006-04-14
Published in:
- Nature reviews. Molecular cell biology. - 2006
Animals
Base Pair Mismatch
DNA Repair
Drug Resistance
Exonucleases
Humans
Models, Molecular
Proliferating Cell Nuclear Antigen
English
By removing biosynthetic errors from newly synthesized DNA, mismatch repair (MMR) improves the fidelity of DNA replication by several orders of magnitude. Loss of MMR brings about a mutator phenotype, which causes a predisposition to cancer. But MMR status also affects meiotic and mitotic recombination, DNA-damage signalling, apoptosis and cell-type-specific processes such as class-switch recombination, somatic hypermutation and triplet-repeat expansion. This article reviews our current understanding of this multifaceted DNA-repair system in human cells.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1038/nrm1907
- PMID 16612326
- Persistent URL
- https://sonar.ch/global/documents/219405
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