Back
Full-text
Journal article

From unwinding to clamping - the DEAD box RNA helicase family.

  • Linder P Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, 1, rue Michel Servet, 1211 Genève 4, Switzerland. Patrick.Linder@unige.ch
  • Jankowsky E
  • 2011-07-23
Published in:
  • Nature reviews. Molecular cell biology. - 2011
Adenosine Triphosphate
Animals
Binding Sites
DEAD-box RNA Helicases
Eukaryotic Initiation Factor-4A
Humans
Models, Biological
Models, Molecular
Nucleocytoplasmic Transport Proteins
Protein Biosynthesis
Protein Structure, Tertiary
RNA, Messenger
Saccharomyces cerevisiae
English RNA helicases of the DEAD box family are present in all eukaryotic cells and in many bacteria and Archaea. These highly conserved enzymes are required for RNA metabolism from transcription to degradation and are therefore important players in gene expression. DEAD box proteins use ATP to unwind short duplex RNA in an unusual fashion and remodel RNA-protein complexes, but they can also function as ATP-dependent RNA clamps to provide nucleation centres that establish larger RNA-protein complexes. Structural, mechanistic and molecular biological studies have started to reveal how these conserved proteins can perform such diverse functions and how accessory proteins have a central role in their regulation.
Language
  • English
Open access status
green
Identifiers
Persistent URL
https://sonar.ch/global/documents/220411
Statistics
Document views: 41 File downloads:
  • Full-text: 0