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Bordetella holmesii infection: current knowledge and a vision for future research.
Journal article

Bordetella holmesii infection: current knowledge and a vision for future research.

  • Pittet LF Department of Pediatrics, Division of General Paediatrics, Children's Hospital, University Hospitals of Geneva, 6 Rue Willy-Donzé, 1211 Geneva 14, Switzerland.
  • Posfay-Barbe KM
  • 2015-06-13
Published in:
  • Expert review of anti-infective therapy. - 2015
16S ribosomal RNA sequencing
Bordetella holmesii
Bordetella pertussis
Bordetella-specific polymerase chain reaction
arthritis
bacteremia
bhoE
cellulitis
endocarditis
epidemiology
hIS1001
insertion sequences IS481
matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
meningitis
pericarditis
pertussis-like illness
pneumonia
recA
vaccination
Bordetella
Bordetella Infections
Humans
English Bordetella holmesii is a recently recognized Gram-negative bacterium causing both pertussis-like respiratory symptoms and invasive infections, such as bacteremia, pneumonia, meningitis, arthritis, pericarditis and endocarditis. Few data are available on its epidemiological characteristics, mostly related to respiratory infections. However, these are frequently misdiagnosed as a Bordetella pertussis infection as most diagnostic tests routinely used are not species-specific, thus biasing the epidemiological studies of both strains, as well as the efficacy studies on pertussis vaccination. There is no accepted agreement on treatment and it remains unknown if antimicrobial prophylaxis is indicated in certain clinical settings. We review here the current knowledge on B. holmesii and the need for further research.
Language
  • English
Open access status
closed
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https://sonar.ch/global/documents/220523
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