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Transportable hyperpolarized metabolites.

  • Ji X Ecole Polytechnique Fédérale de Lausanne, Institut des Sciences et Ingénierie Chimiques, Lausanne 1015, Switzerland.
  • Bornet A Ecole Polytechnique Fédérale de Lausanne, Institut des Sciences et Ingénierie Chimiques, Lausanne 1015, Switzerland.
  • Vuichoud B Ecole Polytechnique Fédérale de Lausanne, Institut des Sciences et Ingénierie Chimiques, Lausanne 1015, Switzerland.
  • Milani J Ecole Polytechnique Fédérale de Lausanne, Institut des Sciences et Ingénierie Chimiques, Lausanne 1015, Switzerland.
  • Gajan D Univ Lyon, CNRS, Université Claude Bernard Lyon 1, ENS de Lyon, Institut des Sciences Analytiques, UMR 5280, 5 rue de la Doua, 69100 Villeurbanne, France.
  • Rossini AJ Ecole Polytechnique Fédérale de Lausanne, Institut des Sciences et Ingénierie Chimiques, Lausanne 1015, Switzerland.
  • Emsley L Ecole Polytechnique Fédérale de Lausanne, Institut des Sciences et Ingénierie Chimiques, Lausanne 1015, Switzerland.
  • Bodenhausen G Ecole Polytechnique Fédérale de Lausanne, Institut des Sciences et Ingénierie Chimiques, Lausanne 1015, Switzerland.
  • Jannin S Ecole Polytechnique Fédérale de Lausanne, Institut des Sciences et Ingénierie Chimiques, Lausanne 1015, Switzerland.
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  • 2017-01-11
Published in:
  • Nature communications. - 2017
Alanine
Carbon Isotopes
Cyclic N-Oxides
Glycine
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Metabolomics
Specimen Handling
Spin Labels
English Nuclear spin hyperpolarization of 13C-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by MRI. However, because of the short lifetime of the hyperpolarized magnetization (typically <1 min), the polarization process must be carried out close to the point of use. Here we introduce a concept that markedly extends hyperpolarization lifetimes and enables the transportation of hyperpolarized metabolites. The hyperpolarized sample can thus be removed from the polarizer and stored or transported for use at remote MRI or NMR sites. We show that hyperpolarization in alanine and glycine survives 16 h storage and transport, maintaining overall polarization enhancements of up to three orders of magnitude.
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  • English
Open access status
gold
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Persistent URL
https://sonar.ch/global/documents/22180
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