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Nrf2--A regulator of keratinocyte redox signaling.
Journal article

Nrf2--A regulator of keratinocyte redox signaling.

  • Schäfer M Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology, 8093 Zurich, Switzerland. Electronic address: matthias.schaefer@biol.ethz.ch.
  • Werner S Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology, 8093 Zurich, Switzerland. Electronic address: sabine.werner@biol.ethz.ch.
  • 2015-04-28
Published in:
  • Free radical biology & medicine. - 2015
Chemoprevention
Inflammation
Nrf2
Oxidative stress
Skin cancer
UV
Wound healing
Animals
Humans
Inflammation
Keratinocytes
NF-E2-Related Factor 2
Oxidation-Reduction
Oxidative Stress
Signal Transduction
Skin
Skin Neoplasms
English The skin is frequently exposed to environmental challenges, such as UV irradiation, toxic chemicals, and mechanical wounding. These insults cause an increase in the levels of reactive oxygen species, resulting in oxidative stress and concomitant inflammation, skin aging, and even cancer development. Therefore, an efficient antioxidant defense strategy is of major importance in this tissue. Since the Nrf2 transcription factor regulates a battery of genes involved in the defense against reactive oxygen species and in compound metabolism, it plays a key role in skin homeostasis, repair, and disease. In this review we summarize current knowledge on the expression and function of Nrf2 in normal skin and its role in the acute and chronic UV response as well as in the pathogenesis of epithelial skin cancer and of different inflammatory skin diseases. Finally, we discuss the potential of Nrf2-activating compounds for skin protection under stress conditions and for the treatment of major human skin disorders.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/223286
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