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Resources for Systems Genetics.
Journal article

Resources for Systems Genetics.

  • Williams RW Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, 77 S. Manassas Street, Memphis, TN, 38163, USA. rwilliams@uthsc.edu.
  • Williams EG Department of Biology, Institute for Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.
  • 2016-12-10
Published in:
  • Methods in molecular biology (Clifton, N.J.). - 2017
Collaborative Cross (CC)
Congenic lines
Consomic and chromosome substitution lines
Diversity outcross (DO)
Gene-by-environment interactions (G × E)
Genetic reference population (GRP)
Heterogeneous stock (HS)
Hybrid diversity panel (HDP)
RI intercross (RIX) and RI backcross (RIB) progeny
Recombinant congenic strains
Recombinant inbred (RI)
Reduced complexity cross (RCC)
Animals
Breeding
Chromosome Mapping
Crosses, Genetic
Genetic Techniques
Genetics, Population
Genomics
Genotype
Humans
Hybridization, Genetic
Inbreeding
Mutation
Quantitative Trait Loci
Research Design
English A key characteristic of systems genetics is its reliance on populations that vary to a greater or lesser degree in genetic complexity-from highly admixed populations such as the Collaborative Cross and Diversity Outcross to relatively simple crosses such as sets of consomic strains and reduced complexity crosses. This protocol is intended to help investigators make more informed decisions about choices of resources given different types of questions. We consider factors such as costs, availability, and ease of breeding for common scenarios. In general, we recommend using complementary resources and minimizing depth of resampling of any given genome or strain.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/223441
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