Denervation leads to volume regression in breast cancer.
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Kappos EA
Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland; Department of Neuropathology, Institute of Pathology, University Hospital Basel, Schönbeinstrasse 40, 4031 Basel, Switzerland. Electronic address: Elisabeth.Kappos@usb.ch.
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Engels PE
Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland; Department of Neuropathology, Institute of Pathology, University Hospital Basel, Schönbeinstrasse 40, 4031 Basel, Switzerland.
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Tremp M
Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland; Department of Neuropathology, Institute of Pathology, University Hospital Basel, Schönbeinstrasse 40, 4031 Basel, Switzerland.
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Sieber PK
Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland; Department of Neuropathology, Institute of Pathology, University Hospital Basel, Schönbeinstrasse 40, 4031 Basel, Switzerland.
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von Felten S
Clinical Trial Unit, Department of Clinical Research, University Hospital Basel, Schanzenstrasse 55, 4031 Basel, Switzerland.
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Madduri S
Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland; Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.
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Meyer Zu Schwabedissen M
Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland.
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Fischmann A
Division of Neuroradiology, Department of Radiology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
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Schaefer DJ
Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland.
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Kalbermatten DF
Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland.
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Published in:
- Journal of plastic, reconstructive & aesthetic surgery : JPRAS. - 2018
English
The nervous system plays a key role in controlling the dynamic functions of multicellular complex organisms. Although peripheral nerves are supposed to play a pivotal role in tumor growth and dissemination, little experimental evidence exists to date. We assessed the effect of denervation on breast cancer growth by magnetic resonance imaging (MRI) in rats. Human breast cancer cells were implanted into adipofascial flaps with intact or surgically excised supplying nerve. Tumor volumes were measured 2 and 8 weeks after implantation by in vivo MRI. Results were validated by histology. Postoperative tumor volumes at 2 and 8 weeks were reduced by 76% (95% CI: 22-93%) in the denervated groups. Tumor area as determined histologically was reduced by 70% (95% CI: 60-78%). Thus, peripheral denervation may be an effective surgical approach for the palliative treatment of locally progressing or uncontrollable breast cancer.
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Open access status
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bronze
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Persistent URL
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https://sonar.ch/global/documents/223736
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