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How T lymphocytes recognize lipid antigens.
Journal article

How T lymphocytes recognize lipid antigens.

  • De Libero G Experimental Immunology, Department of Research, University Hospital, University of Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland. gennaro.delibero@unibas.ch
  • Mori L
  • 2006-09-05
Published in:
  • FEBS letters. - 2006
Animals
Antigen Presentation
Antigens
Biological Transport
Humans
Lipid Metabolism
Lipids
T-Lymphocytes
English Recognition of lipid antigens by T lymphocytes is well established. Lipids are recognized by T cells when presented in association with CD1 antigen-presenting molecules. Both microbial and self lipids stimulate specific T lymphocytes, thus participating in immune reactions during infections and autoimmune diseases. The immune system uses a variety of strategies to solubilise lipid antigens, to facilitate their internalization, processing, and loading on CD1 molecules. Recent studies in the field of lipid antigen presentation have revealed new mechanisms which allow the immune system to sense lipids as stimulatory antigens.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/224482
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