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mTOR signaling in disease.
Journal article

mTOR signaling in disease.

  • Dazert E Biozentrum, University of Basel, CH4056 Basel, Switzerland.
  • Hall MN
  • 2011-10-04
Published in:
  • Current opinion in cell biology. - 2011
Animals
Cell Proliferation
Disease Models, Animal
Humans
Mammals
Neoplasms
Signal Transduction
TOR Serine-Threonine Kinases
English The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in response to nutrients, growth factors and cellular energy. Dysregulated mTOR signaling has been implicated in major disease. Here we review recent findings on the role of mTOR in cancer, metabolic disorders, neurological diseases, and inflammation.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/224513
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