Leptomeningeal and Intraparenchymal Blood Barrier Disruption in a MOG-IgG-Positive Patient.
- Mohseni SH Department of Radiology, Slagelse Hospital, Slagelse, Denmark.
- Skejoe HPB Department of Radiology, Aleris-Hamlet Hospital, Copenhagen, Denmark.
- Wuerfel J Medical Image Analysis Center Basel and Department of Biomedical Engineering, University Basel, Switzerland.
- Paul F Clinical and Experimental Multiple Sclerosis Research Center and NeuroCure Clinical Research Center, Department of Neurology, Charité-Universitätsmedizin Berlin, Germany.
- Reindl M Clinical Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
- Jarius S Molecular Neuroimmunology Group, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany.
- Asgari N Department of Neurology, Slagelse Hospital, Institute of Regional Health Research, Denmark.
- 2019-03-06
Published in:
- Case reports in neurological medicine. - 2018
English
Background
Recently, pathogenic serum immunoglobulin G (IgG) autoantibodies to myelin oligodendrocyte glycoprotein (MOG) have been detected in a subgroup of patients with central nervous system (CNS) demyelination, including in patients with myelitis. Relatively little is known so far about leptomeningeal involvement in MOG-IgG-positive myelitis.
Findings
We report the case of a 30-year-old previously healthy woman presenting with longitudinally extensive transverse myelitis and tetraparesis, in whom both the leptomeningeal barrier and the blood-brain barrier (BBB) were altered, as demonstrated by gadolinium-enhanced MRI during relapse. Blood samples taken at onset and four years later were retrospectively found positive for MOG-IgG.
Conclusion
Our findings demonstrate that spinal leptomeningeal enhancement (LME) can occur in MOG-IgG-positive encephalomyelitis (EM) and may accompany intraparenchymal BBB breakdown.
Recently, pathogenic serum immunoglobulin G (IgG) autoantibodies to myelin oligodendrocyte glycoprotein (MOG) have been detected in a subgroup of patients with central nervous system (CNS) demyelination, including in patients with myelitis. Relatively little is known so far about leptomeningeal involvement in MOG-IgG-positive myelitis.
Findings
We report the case of a 30-year-old previously healthy woman presenting with longitudinally extensive transverse myelitis and tetraparesis, in whom both the leptomeningeal barrier and the blood-brain barrier (BBB) were altered, as demonstrated by gadolinium-enhanced MRI during relapse. Blood samples taken at onset and four years later were retrospectively found positive for MOG-IgG.
Conclusion
Our findings demonstrate that spinal leptomeningeal enhancement (LME) can occur in MOG-IgG-positive encephalomyelitis (EM) and may accompany intraparenchymal BBB breakdown.
- Language
-
- English
- Open access status
- gold
- Identifiers
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- DOI 10.1155/2018/1365175
- PMID 30834146
- Persistent URL
- https://sonar.ch/global/documents/224562
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