Low serum DHEA-S is associated with impaired lung function in women.
- Pesce G Sorbonne Université and INSERM UMR-S 1136, Epidemiology of Allergic and Respiratory Diseases (EPAR), Pierre Louis Institute of Epidemiology and Public Health (IPLESP), Saint-Antoine Medical School, F-75012, Paris, France.
- Triebner K Department of Clinical Science, University of Bergen, Bergen, Norway.
- van der Plaat DA Population Health and Occupational Disease, National Heart and Lung Institute (NHLI), Imperial College, London, United Kingdom.
- Courbon D INSERM UMR 1152, Pathophysiology and Epidemiology of Respiratory Diseases, Paris, France. University Paris Diderot Paris 7, UMR 1152, F-75890, Paris, France.
- Hustad S Department of Clinical Science, University of Bergen, Bergen, Norway.
- Sigsgaard T Institute of Public Health, Aarhus University, Aarhus, Denmark.
- Nowak D Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Comprehensive Pneumology Centre Munich, German Centre for Lung Research (DZL), Munich, Germany.
- Heinrich J Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Comprehensive Pneumology Centre Munich, German Centre for Lung Research (DZL), Munich, Germany.
- Anto JM ISGlobal, Barcelona, Spain.
- Dorado-Arenas S Pulmonology Department, Galdakao Hospital, Bizkaia, Spain.
- Martinez-Moratalla J Servicio de Neumología del Hospital General Universitario de Albacete. Albacete, Spain.
- Gullon-Blanco JA Pneumology Deptarment, Universitary Hospital San Agustín, Avilés, Spain.
- Sanchez-Ramos JL Department of Nursing, University of Huelva, Huelva, Spain.
- Raherison C Université de Bordeaux, Inserm, Bordeaux Population Health Research Center, Team EPICENE, UMR 1219, Bordeaux, France.
- Pin I Pédiatrie CHU Grenoble Alpes; Inserm Unité E2R2H; Université Grenoble Alpes, Grenoble, France.
- Demoly P Sorbonne Université and INSERM UMR-S 1136, Epidemiology of Allergic and Respiratory Diseases (EPAR), Pierre Louis Institute of Epidemiology and Public Health (IPLESP), Saint-Antoine Medical School, F-75012, Paris, France.
- Gislason T Department of Sleep, Landspitali, The National University Hospital of Iceland, Reykjavík (Iceland).
- Torén K Occupational and environmental medicine, School of Public Health, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
- Forsberg B Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
- Lindberg E Department of Medical Sciences: Respiratory, Allergy and Sleep research, Uppsala University, Uppsala, Sweden.
- Zemp E Department Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
- Jogi R Lung Clinic, Tartu University Hospital, Tartu, Estonia.
- Probst-Hensch N Department Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
- Dharmage SC Allergy and Lung Health Unit, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
- Jarvis D National Heart and Lung Institute, Imperial College, London UK.
- Garcia-Aymerich J ISGlobal, Barcelona, Spain.
- Marcon A Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
- Gómez-Real F Department of Clinical Science, University of Bergen, Bergen, Norway.
- Leynaert B Inserm UMR-S 1168, VIMA, Villejuif, France.
- 2020-06-13
Published in:
- EClinicalMedicine. - 2020
English
Background
Emerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. This study investigated whether serum dehydroepiandrosterone sulfate (DHEA-S), a key precursor of both androgens and estrogens in peripheral tissues, was related to lung function in adult women participating in the European Community Respiratory Health Survey (ECRHS).
Methods
Lung function and serum DHEA-S concentrations were measured in n = 2,045 and n = 1,725 women in 1999-2002 and in 2010-2013, respectively. Cross-sectional associations of DHEA-S levels (expressed as age-adjusted z-score) with spirometric outcomes were investigated, adjusting for smoking habits, body mass index, menopausal status, and use of corticosteroids. Longitudinal associations of DHEA-S levels in 1999-2002 with incidence of restrictive pattern and airflow limitation in 2010-2013 were also assessed.
Findings
Women with low DHEA-S (z-score<-1) had lower FEV1 (% of predicted, adjusted difference: -2.2; 95%CI: -3.5 to -0.9) and FVC (-1.7; 95%CI: -2.9 to -0.5) and were at a greater risk of having airflow limitation and restrictive pattern on spirometry than women with higher DHEA-S levels. In longitudinal analyses, low DHEA-S at baseline was associated with a greater incidence of airflow limitation after an 11-years follow-up (incidence rate ratio, 3.43; 95%CI: 1.91 to 6.14).
Interpretation
Low DHEA-S levels in women were associated with impaired lung function and a greater risk of developing airflow limitation later in adult life. Our findings provide new evidence supporting a role of DHEA-S in respiratory health.
Funding
EU H2020, grant agreement no.633212.
Emerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. This study investigated whether serum dehydroepiandrosterone sulfate (DHEA-S), a key precursor of both androgens and estrogens in peripheral tissues, was related to lung function in adult women participating in the European Community Respiratory Health Survey (ECRHS).
Methods
Lung function and serum DHEA-S concentrations were measured in n = 2,045 and n = 1,725 women in 1999-2002 and in 2010-2013, respectively. Cross-sectional associations of DHEA-S levels (expressed as age-adjusted z-score) with spirometric outcomes were investigated, adjusting for smoking habits, body mass index, menopausal status, and use of corticosteroids. Longitudinal associations of DHEA-S levels in 1999-2002 with incidence of restrictive pattern and airflow limitation in 2010-2013 were also assessed.
Findings
Women with low DHEA-S (z-score<-1) had lower FEV1 (% of predicted, adjusted difference: -2.2; 95%CI: -3.5 to -0.9) and FVC (-1.7; 95%CI: -2.9 to -0.5) and were at a greater risk of having airflow limitation and restrictive pattern on spirometry than women with higher DHEA-S levels. In longitudinal analyses, low DHEA-S at baseline was associated with a greater incidence of airflow limitation after an 11-years follow-up (incidence rate ratio, 3.43; 95%CI: 1.91 to 6.14).
Interpretation
Low DHEA-S levels in women were associated with impaired lung function and a greater risk of developing airflow limitation later in adult life. Our findings provide new evidence supporting a role of DHEA-S in respiratory health.
Funding
EU H2020, grant agreement no.633212.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.1016/j.eclinm.2020.100389
- PMID 32529179
- Persistent URL
- https://sonar.ch/global/documents/225207
Statistics
Document views: 10
File downloads:
- fulltext.pdf: 0