Journal article
Roadmap: proton therapy physics and biology.
- Paganetti H Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, UNITED STATES.
- Beltran CJ Radiation Oncology, Mayo Clinic, Rochester, Minnesota, UNITED STATES.
- Both S Radiation Oncology, University Medical Center Groningen, Groningen, NETHERLANDS.
- Dong L University of Pennsylvania, Philadelphia, Pennsylvania, UNITED STATES.
- Flanz JB Department of Radiation Oncology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA, Boston, 02114, UNITED STATES.
- Furutani KM Radiation Oncology, Mayo Clinic, Rochester, UNITED STATES.
- Grassberger C Massachusetts General Hospital, Boston, UNITED STATES.
- Grosshans DR Radiation Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston , UNITED STATES.
- Knopf AC UMCG Groningen, Groningen, NETHERLANDS.
- Langendijk JA , UMCG, Groningen, NETHERLANDS.
- Nyström H The Skandion Clinic, Uppsala, SWEDEN.
- Parodi K Department of Medical Physics, Ludwig-Maximilians-Universität München Fakultät für Physik, München, Bayern, GERMANY.
- Raaymakers BW Department of Radiotherapy, Universitair Medisch Centrum Utrecht, HP Q.00.118, Heidelberglaan 100, 3584 CX Utrecht, THE NETHERLANDS, Utrecht, NETHERLANDS.
- Richter C High Precision Radiotherapy, OncoRay - National Center for Radiation Research in Oncology, University Hospital and Medical Faculty C G Carus, Fetscherstr 74, PF 41, 01307 Dresden, Dresden, Saxony, 01307, GERMANY.
- Sawakuchi GO Radiation Physics, UT MD Anderson Cancer Center, Unit 94, 1515 Holcombe Boulevard, Houston, TX 77030, USA, Houston, Texas, 77030, UNITED STATES.
- Schippers JM Nuclear Energy and Safety Research Department, Paul Scherrer Institute, WBGA-C16, CH-5232 Villigen-PSI, Villigen, SWITZERLAND.
- Shaitelman SF University of Texas MD Anderson Cancer Center, Houston, Texas, UNITED STATES.
- Teo K School of medicine, University of Pennsylvania, Philadelphia, Pennsylvania, UNITED STATES.
- Unkelbach J University of Zurich, Zurich, ZH, SWITZERLAND.
- Wohlfahrt P Department of Radiation Oncology, Massachusetts General Hospital, Boston, UNITED STATES.
- Lomax AJ Department of Radiation Medicine, Paul Scherrer Institute, CH-5232 Villigen PSI, Villigen, SWITZERLAND.
- 2020-11-23
Published in:
- Physics in medicine and biology. - 2020
English
The treatment of cancer with proton radiation therapy was first suggested in 1946 followed by the first treatments in the 1950s. As of 2020, almost 200,000 patients have been treated with proton beams worldwide and the number of operating proton therapy facilities will soon reach one hundred. Proton therapy has long moved from research institutions into hospital-based facilities that are increasingly being utilized with workflows similar to conventional radiation therapy. While proton therapy has become mainstream and has established itself as a treatment option for many cancers, it is still an area of active research for various reasons: the advanced dose shaping capabilities of proton therapy cause susceptibility to uncertainties, the high degrees of freedom in dose delivery offer room for further improvements, the limited experience and understanding of optimizing pencil beam scanning, and the biological effects differ from photon radiation. In addition to these challenges and opportunities currently being investigated, there is an economic aspect because proton therapy treatments are, on average, still more expensive compared to conventional photon based treatment options. This roadmap highlights the current state and future direction in proton therapy categorized into four different themes, "improving efficiency", "improving planning and delivery", "improving imaging", and "improving patient selection".
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1088/1361-6560/abcd16
- PMID 33227715
- Persistent URL
- https://sonar.ch/global/documents/226263
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