Journal article
Convergence of cortical types and functional motifs in the human mesiotemporal lobe
-
Paquola, Casey
ORCID
Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
-
Benkarim, Oualid
Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
-
DeKraker, Jordan
Brain and Mind Institute, University of Western Ontario, London, Canada
-
Larivière, Sara
ORCID
Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
-
Frässle, Stefan
ORCID
Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich & ETH Zurich, Zurich, Switzerland
-
Royer, Jessica
Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
-
Tavakol, Shahin
Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
-
Valk, Sofie
Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
-
Bernasconi, Andrea
Neuroimaging Of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
-
Bernasconi, Neda
Neuroimaging Of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
-
Khan, Ali
Brain and Mind Institute, University of Western Ontario, London, Canada
-
Evans, Alan C
McGill Centre for Integrative Neuroscience, McGill University, Montreal, Canada
-
Razi, Adeel
ORCID
Monash University, Melbourne, Australia
-
Smallwood, Jonathan
University of York, York, United Kingdom
-
Bernhardt, Boris C
ORCID
Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
Show more…
Published in:
- eLife. - eLife Sciences Publications, Ltd. - 2020, vol. 9
English
The mesiotemporal lobe (MTL) is implicated in many cognitive processes, is compromised in numerous brain disorders, and exhibits a gradual cytoarchitectural transition from six-layered parahippocampal isocortex to three-layered hippocampal allocortex. Leveraging an ultra-high-resolution histological reconstruction of a human brain, our study showed that the dominant axis of MTL cytoarchitectural differentiation follows the iso-to-allocortical transition and depth-specific variations in neuronal density. Projecting the histology-derived MTL model to in-vivo functional MRI, we furthermore determined how its cytoarchitecture underpins its intrinsic effective connectivity and association to large-scale networks. Here, the cytoarchitectural gradient was found to underpin intrinsic effective connectivity of the MTL, but patterns differed along the anterior-posterior axis. Moreover, while the iso-to-allocortical gradient parametrically represented the multiple-demand relative to task-negative networks, anterior-posterior gradients represented transmodal versus unimodal networks. Our findings establish that the combination of micro- and macrostructural features allow the MTL to represent dominant motifs of whole-brain functional organisation.
-
Language
-
-
Open access status
-
gold
-
Identifiers
-
-
Persistent URL
-
https://sonar.ch/global/documents/22661
Statistics
Document views: 15
File downloads: