Convergence of cortical types and functional motifs in the human mesiotemporal lobe
Journal article

Convergence of cortical types and functional motifs in the human mesiotemporal lobe

  • Paquola, Casey ORCID Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
  • Benkarim, Oualid Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
  • DeKraker, Jordan Brain and Mind Institute, University of Western Ontario, London, Canada
  • Larivière, Sara ORCID Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
  • Frässle, Stefan ORCID Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich & ETH Zurich, Zurich, Switzerland
  • Royer, Jessica Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
  • Tavakol, Shahin Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
  • Valk, Sofie Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
  • Bernasconi, Andrea Neuroimaging Of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
  • Bernasconi, Neda Neuroimaging Of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
  • Khan, Ali Brain and Mind Institute, University of Western Ontario, London, Canada
  • Evans, Alan C McGill Centre for Integrative Neuroscience, McGill University, Montreal, Canada
  • Razi, Adeel ORCID Monash University, Melbourne, Australia
  • Smallwood, Jonathan University of York, York, United Kingdom
  • Bernhardt, Boris C ORCID Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
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  • 2020-11-4
Published in:
  • eLife. - eLife Sciences Publications, Ltd. - 2020, vol. 9
English The mesiotemporal lobe (MTL) is implicated in many cognitive processes, is compromised in numerous brain disorders, and exhibits a gradual cytoarchitectural transition from six-layered parahippocampal isocortex to three-layered hippocampal allocortex. Leveraging an ultra-high-resolution histological reconstruction of a human brain, our study showed that the dominant axis of MTL cytoarchitectural differentiation follows the iso-to-allocortical transition and depth-specific variations in neuronal density. Projecting the histology-derived MTL model to in-vivo functional MRI, we furthermore determined how its cytoarchitecture underpins its intrinsic effective connectivity and association to large-scale networks. Here, the cytoarchitectural gradient was found to underpin intrinsic effective connectivity of the MTL, but patterns differed along the anterior-posterior axis. Moreover, while the iso-to-allocortical gradient parametrically represented the multiple-demand relative to task-negative networks, anterior-posterior gradients represented transmodal versus unimodal networks. Our findings establish that the combination of micro- and macrostructural features allow the MTL to represent dominant motifs of whole-brain functional organisation.
Language
  • English
Open access status
gold
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Persistent URL
https://sonar.ch/global/documents/22661
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