Estrogen-induced cardiorenal protection: potential cellular, biochemical, and molecular mechanisms
- Dubey, Raghvendra K. Clinic for Endocrinology, Department of Obstetrics and Gynecology, University Hospital Zurich, 8091 Zurich, Switzerland
- Jackson, Edwin K. Department of Pharmacology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213; and
Published in:
- American Journal of Physiology-Renal Physiology. - American Physiological Society. - 2001, vol. 280, no. 3, p. F365-F388
English
A number of cellular and biochemical processes are involved in the pathophysiology of glomerular and vascular remodeling, leading to renal and vascular disorders, respectively. Although estradiol protects the renal and cardiovascular systems, the mechanisms involved remain unclear. In this review we provide a discussion of the cellular, biochemical, and molecular mechanisms by which estradiol may exert protective effects on the kidneys and vascular wall. In this regard, we consider the possible role of genomic vs. nongenomic mechanisms and estrogen receptor-dependent vs. estrogen receptor-independent mechanisms in mediating the protective effects of estradiol on the renal and cardiovascular systems.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1152/ajprenal.2001.280.3.f365
- ISSN 1931-857X
- Persistent URL
- https://sonar.ch/global/documents/22750
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