Journal article
New trends in the production of pharmaceutical granules: batch versus continuous processing.
- Leuenberger H Institute of Pharmaceutical Technology, Pharmacenter of the University of Basel, Basel, Switzerland. hans.leuenberger@unibas.ch
- 2001-10-26
Published in:
- European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. - 2001
English
In the pharmaceutical industry, the production of granules is based on a batch concept. This concept offers many advantages with respect to quality assurance as a batch can be accepted or rejected. However, the scale-up of the batch size may lead to problems. The variety of the equipment involved often does not facilitate the scale-up process. In order to avoid scale-up problems, continuous or semi-continuous processes have to be evaluated as alternatives to a batch production. Thus, a quasi-continuous production line is presented, which permits the production of small-scale batches, e.g. for clinical trials and for large-scale batches using the same equipment.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/s0939-6411(01)00199-0
- PMID 11677071
- Persistent URL
- https://sonar.ch/global/documents/227725
Statistics
Document views: 35
File downloads: