The inhibition of tyrosinase by pyridinones
- Hider, R C Department of Pharmacy, King's College London (Chelsea Campus), Manresa Road, London SW3 6LX, U.K.
- Lerch, K Biochemisches Institut, Universität Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland
Published in:
- Biochemical Journal. - Portland Press Ltd.. - 1989, vol. 257, no. 1, p. 289-290
English
3-Hydroxypyridine-4-ones have potential as orally active chelators of iron(III) and therefore may find application in the treatment of thalassaemia. An undesirable feature of these molecules is that they inhibit tyrosinase. We have established that alkyl substitution at position 2 in the aromatic ring minimizes interaction with tyrosinase and does so without appreciably influencing the affinity for iron(III).
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1042/bj2570289
- ISSN 0264-6021
- Persistent URL
- https://sonar.ch/global/documents/228940
Statistics
Document views: 22
File downloads:
- Full-text: 0