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Resident-Memory T Cells in Tissue-Restricted Immune Responses: For Better or Worse?

  • Steinbach K Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
  • Vincenti I Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
  • Merkler D Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
  • 2018-12-18
Published in:
  • Frontiers in immunology. - 2018
autoimmune
chronic
infection
inflammation
resident memory T cells
Animals
CD8-Positive T-Lymphocytes
Humans
Immunologic Memory
Inflammation
Organ Specificity
English Tissue-resident-memory CD8+ T cells (TRM) have been described as a non-circulating memory T cell subset that persists at sites of previous infection. While TRM in all non-lymphoid organs probably share a core signature differentiation pathway, certain aspects of their maintenance and effector functions may vary. It is well-established that TRM provide long-lived protective immunity through immediate effector function and accelerated recruitment of circulating immune cells. Besides immune defense against pathogens, other immunological roles of TRM are less well-studied. Likewise, evidence of a putative detrimental role of TRM for inflammatory diseases is only beginning to emerge. In this review, we discuss the protective and harmful role of TRM in organ-specific immunity and immunopathology as well as prospective implications for immunomodulatory therapy.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/229620
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