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Journal article

Where is mTOR and what is it doing there?

  • Betz C Biozentrum, University of Basel, CH-4056 Basel, Switzerland.
  • Hall MN
  • 2014-01-04
Published in:
  • The Journal of cell biology. - 2013
Animals
Humans
Mechanistic Target of Rapamycin Complex 1
Mechanistic Target of Rapamycin Complex 2
Models, Biological
Multiprotein Complexes
Protein Transport
TOR Serine-Threonine Kinases
English Target of rapamycin (TOR) forms two conserved, structurally distinct kinase complexes termed TOR complex 1 (TORC1) and TORC2. Each complex phosphorylates a different set of substrates to regulate cell growth. In mammals, mTOR is stimulated by nutrients and growth factors and inhibited by stress to ensure that cells grow only during favorable conditions. Studies in different organisms have reported localization of TOR to several distinct subcellular compartments. Notably, the finding that mTORC1 is localized to the lysosome has significantly enhanced our understanding of mTORC1 regulation. Subcellular localization may be a general principle used by TOR to enact precise spatial and temporal control of cell growth.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://sonar.ch/global/documents/231607
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