Sestrin1, a tumor suppressor that can be rescued.
- Donaldson MC Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
- Katanayeva N Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
- Oricchio E Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
- 2017-12-07
Published in:
- Molecular & cellular oncology. - 2017
English
SESTRIN1 is a tumor suppressor in follicular lymphoma that controls mTORC1 activity and it is inactivated by chromosomal deletions or epigenetically silenced by mutant EZH2Y641X. Pharmacological inhibition of EZH2 promotes SESTRIN1 re-expression and it restores its tumor suppressive activity, suggesting the possibility to epigenetically control mTORC1 activity.
- Language
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- English
- Open access status
- hybrid
- Identifiers
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- DOI 10.1080/23723556.2017.1365107
- PMID 29209652
- Persistent URL
- https://sonar.ch/global/documents/231666
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