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Heart failure in cardiomyopathies: a position paper from the Heart Failure Association of the European Society of Cardiology.

  • Seferović PM University of Belgrade Faculty of Medicine, Belgrade, Serbia.
  • Polovina M University of Belgrade Faculty of Medicine, Belgrade, Serbia.
  • Bauersachs J Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany.
  • Arad M Cardiomyopathy Clinic and Heart Failure Institute, Leviev Heart Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Gal TB Department of Cardiology, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Lund LH Department of Medicine, Karolinska Institutet, and Heart and Vascular Theme, Karolinska University Hospital, Stockholm, Sweden.
  • Felix SB Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
  • Arbustini E Centre for Inherited Cardiovascular Diseases, IRCCS Foundation, University Hospital Policlinico San Matteo, Pavia, Italy.
  • Caforio ALP Division of Cardiology, Department of Cardiological, Thoracic and Vascular Sciences, University of Padua, Padua, Italy.
  • Farmakis D University of Cyprus Medical School, Nicosia, Cyprus; Heart Failure Unit, Department of Cardiology, Athens University Hospital Attikon, National and Kapodistrian University of Athens, Athens, Greece.
  • Filippatos GS University of Cyprus Medical School, Nicosia, Cyprus; Heart Failure Unit, Department of Cardiology, Athens University Hospital Attikon, National and Kapodistrian University of Athens, Athens, Greece.
  • Gialafos E Second Department of Cardiology, Heart Failure and Preventive Cardiology Section, Henry Dunant Hospital, Athens, Greece.
  • Kanjuh V Serbian Academy of Sciences and Arts, Belgrade, Serbia.
  • Krljanac G University of Belgrade Faculty of Medicine, Belgrade, Serbia.
  • Limongelli G Department of Cardiothoracic Sciences, Università della Campania 'Luigi VanvitellI', Monaldi Hospital, AORN Colli, Centro di Ricerca Cardiovascolare, Ospedale Monaldi, AORN Colli, Naples, Italy, and UCL Institute of Cardiovascular Science, London, UK.
  • Linhart A Second Department of Medicine, Department of Cardiovascular Medicine, General University Hospital, Charles University in Prague, Prague, Czech Republic.
  • Lyon AR National Heart and Lung Institute, Imperial College London and Royal Brompton Hospital, London, UK.
  • Maksimović R University of Belgrade Faculty of Medicine, Belgrade, Serbia.
  • Miličić D Department of Cardiovascular Diseases, University Hospital Center Zagreb, University of Zagreb, Zagreb, Croatia.
  • Milinković I Department of Cardiology, Clinical Center of Serbia, Belgrade, Serbia.
  • Noutsias M Mid-German Heart Center, Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle, Halle, Germany.
  • Oto A Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Oto Ö Department of Cardiovascular Surgery, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey.
  • Pavlović SU University of Belgrade Faculty of Medicine, Belgrade, Serbia.
  • Piepoli MF Heart Failure Unit, Cardiology, G. da Saliceto Hospital, Piacenza, Italy.
  • Ristić AD University of Belgrade Faculty of Medicine, Belgrade, Serbia.
  • Rosano GMC Department of Medical Sciences, IRCCS San Raffaele, Rome, Italy, and Cardiology Clinical Academic Group, St George's Hospitals NHS Trust University of London, London, UK.
  • Seggewiss H Medizinische Klinik, Kardiologie & Internistische Intensivmedizin, Klinikum Würzburg-Mitte, Würzburg, Germany.
  • Ašanin M University of Belgrade Faculty of Medicine, Belgrade, Serbia.
  • Seferović JP Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Ruschitzka F Department of Cardiology, University Heart Center, Zürich, Switzerland.
  • Čelutkiene J Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
  • Jaarsma T Department of Social and Welfare Studies, Faculty of Health Science, Linköping University, Linköping, Sweden.
  • Mueller C Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Moura B Cardiology Department, Centro Hospitalar São João, Porto, Portugal.
  • Hill L School of Nursing and Midwifery, Queen's University Belfast, Belfast, UK.
  • Volterrani M Department of Cardiology, IRCCS San Raffaele Pisana, Rome, Italy.
  • Lopatin Y Volgograd State Medical University, Regional Cardiology Centre Volgograd, Volgograd, Russia.
  • Metra M Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
  • Backs J Department of Molecular Cardiology and Epigenetics, University of Heidelberg, Heidelberg, Germany.
  • Mullens W BIOMED - Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium.
  • Chioncel O University of Medicine Carol Davila, Bucharest, Romania.
  • de Boer RA Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Anker S Division of Cardiology and Metabolism, Department of Cardiology (CVK), Charité, Berlin, Germany.
  • Rapezzi C Cardiology, Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy.
  • Coats AJS Monash University, Australia, and University of Warwick, Coventry, UK.
  • Tschöpe C Berlin-Brandenburg Center for Regenerative Therapies, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) Berlin, Department of Cardiology, Campus Virchow Klinikum, Charite - Universitaetsmedizin Berlin, Berlin, Germany.
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  • 2019-04-17
Published in:
  • European journal of heart failure. - 2019
Dilated cardiomyopathy
Epidemiology
Heart failure
Hypertrophic cardiomyopathy
Management
Natural history
Pathophysiology
Peripartum cardiomyopathy
Restrictive cardiomyopathy
Cardiomyopathies
Cardiomyopathy, Dilated
Cardiomyopathy, Hypertrophic
Cardiomyopathy, Restrictive
Disease Management
Disease Progression
Female
Heart Failure
Heart Transplantation
Humans
Male
Pregnancy
Pregnancy Complications, Cardiovascular
Puerperal Disorders
Stroke Volume
English Cardiomyopathies are a heterogeneous group of heart muscle diseases and an important cause of heart failure (HF). Current knowledge on incidence, pathophysiology and natural history of HF in cardiomyopathies is limited, and distinct features of their therapeutic responses have not been systematically addressed. Therefore, this position paper focuses on epidemiology, pathophysiology, natural history and latest developments in treatment of HF in patients with dilated (DCM), hypertrophic (HCM) and restrictive (RCM) cardiomyopathies. In DCM, HF with reduced ejection fraction (HFrEF) has high incidence and prevalence and represents the most frequent cause of death, despite improvements in treatment. In addition, advanced HF in DCM is one of the leading indications for heart transplantation. In HCM, HF with preserved ejection (HFpEF) affects most patients with obstructive, and ∼10% of patients with non-obstructive HCM. A timely treatment is important, since development of advanced HF, although rare in HCM, portends a poor prognosis. In RCM, HFpEF is common, while HFrEF occurs later and more frequently in amyloidosis or iron overload/haemochromatosis. Irrespective of RCM aetiology, HF is a harbinger of a poor outcome. Recent advances in our understanding of the mechanisms underlying the development of HF in cardiomyopathies have significant implications for therapeutic decision-making. In addition, new aetiology-specific treatment options (e.g. enzyme replacement therapy, transthyretin stabilizers, immunoadsorption, immunotherapy, etc.) have shown a potential to improve outcomes. Still, causative therapies of many cardiomyopathies are lacking, highlighting the need for the development of effective strategies to prevent and treat HF in cardiomyopathies.
Language
  • English
Open access status
bronze
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Persistent URL
https://sonar.ch/global/documents/231677
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