NSD1 in erythroid differentiation and leukemogenesis.
- Tauchmann S University Children's Hospital Basel (UKBB), Department of Biomedicine, University of Basel, Basel, Switzerland.
- Almosailleakh M University Children's Hospital Basel (UKBB), Department of Biomedicine, University of Basel, Basel, Switzerland.
- Schwaller J University Children's Hospital Basel (UKBB), Department of Biomedicine, University of Basel, Basel, Switzerland.
- 2020-11-25
Published in:
- Molecular & cellular oncology. - 2020
English
We have uncovered a novel role for the nuclear receptor-binding SET domain protein 1 (NSD1) in human and murine erythroid differentiation. Mechanistically, we found that the histone methyltransferase activity of NSD1 is essential for chromatin binding, protein interactions and target gene activation of the erythroid transcriptional master regulator GATA1.
- Language
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- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1080/23723556.2020.1809919
- PMID 33235911
- Persistent URL
- https://sonar.ch/global/documents/231904
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