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Metal Ion-Binding Properties in Aqueous Solution of the Nucleoside Analogue, 5,6-Dichloro-1-(β-ᴅ-ribofuranosyl)benzimidazole (DRB)
Journal article

Metal Ion-Binding Properties in Aqueous Solution of the Nucleoside Analogue, 5,6-Dichloro-1-(β-ᴅ-ribofuranosyl)benzimidazole (DRB)

  • Kapinos, Larisa E. 1Institute of Inorganic Chemistry, University of Basel, Spitalstrasse 51, C H -4056 Basel, Switzerland
  • Song, Bin 2Institute of Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH -4056 Basel, Switzerland
  • Sigel, Helmut 2Institute of Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH -4056 Basel, Switzerland
Published in:
  • Zeitschrift für Naturforschung B. - Walter de Gruyter GmbH. - 1998, vol. 53, no. 8, p. 903-908
General Chemistry
English Abstract The stability constants of the 1:1 complexes formed between Mg2+, Ca2+, Sr2+, Ba2+, Mn2+, Co2+, Ni2+, Cu2+, Zn2+ or Cd2+ (= M2+) and 5,6-dichloro-l-(β-ᴅ-ribofuranosyl)benzim idazole (DRB) were determined by potentiom etric pH titrations in aqueous solution (25 °C; I = 0.5м, NaNO3). The acidity constant of H(DRB)+, the proton being at N3, was measured by the same method and the result was confirmed via spectrophotometry. Based on previously established [L. E. Kapinos, B. Song, H. Sigel, Inorg. Chim . Acta 280, in press (1998)] logммʟ versus Kʜʜʟ straight-line plots for complexes of imidazole-type ligands it is shown for the Mn(DRB)2+ and Zn (DRB)2+ complexes, as examples, that the benzene ring of the benzim idazole residue exerts a steric inhibition for metal ion binding at N3; i.e., the data points for the M(DRB)2+ complexes fall clearly below the straight lines defined by the imidazole- type ligands.
Language
  • English
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https://sonar.ch/global/documents/231994
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