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Coronin 1 is dispensable for leukocyte recruitment and liver injury in concanavalin A-induced hepatitis.
Journal article

Coronin 1 is dispensable for leukocyte recruitment and liver injury in concanavalin A-induced hepatitis.

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  • 2013-07-17
Published in:
  • Immunology letters. - 2013
Concanavalin A
Coronin 1
Hepatitis
Leukocytes
Animals
B-Lymphocytes
CD4-Positive T-Lymphocytes
Cell Adhesion
Cell Movement
Cell Survival
Chemical and Drug Induced Liver Injury
Concanavalin A
Hepatitis
Inflammation
Leukocytes
Liver
Mice
Mice, Inbred C57BL
Mice, Knockout
Microfilament Proteins
Neutrophils
English Coronin 1, a member of the evolutionary conserved coronin protein family, is highly expressed in all leukocytes. In mice and human, genetic inactivation of coronin 1 results in immuno-deficiencies that are linked to a strong reduction of naïve T cell numbers in peripheral organs, while memory/effector T cells, B cells, monocytes and neutrophils are less or not at all affected. Whether or not coronin 1 is important for leukocyte functions such as migration and phagocytosis has been a matter of debate. The current work addresses coronin 1-dependent leukocyte function by analyzing the response of coronin 1-deficient mice in a model of concanavalin A (Con A)-induced liver injury. Histological evaluation and determination of serum liver enzyme levels showed that coronin 1-deficient mice develop signs of acute hepatitis similar to Con A-treated wild type mice despite a reduced activation of T cells in the absence of coronin 1. Furthermore, analysis by intravital microscopy following Con A stimulation revealed that Gr-1+ neutrophils and CD4+ T cell adhesion in the post-sinusoidal venules increased in wild type as well as in coronin 1-deficient mice. These results suggest that coronin 1, while important for naïve T cell survival, is dispensable for other leukocyte function under inflammatory conditions in vivo.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/232120
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