Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure.

• Scholtens S Department of Epidemiology, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
• Postma DS Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
• Moffatt MF Division of Respiratory Sciences, Imperial College, London, United Kingdom.
• Panasevich S Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
• Granell R ALSPAC, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
• Henderson AJ ALSPAC, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
• Melén E Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Sachs' Children's Hospital, Stockholm, Sweden.
• Nyberg F Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Global Epidemiology, AstraZeneca R&D, Mölndal, Sweden.
• Pershagen G Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
• Jarvis D Respiratory Epidemiology and Public Health, Imperial College, London, United Kingdom.
• Ramasamy A Respiratory Epidemiology and Public Health, Imperial College, London, United Kingdom.
• Wjst M Institute of Medical Statistics and Epidemiology (IMSE), Klinikum Rechts der Isar, Technical University, Munich, Germany; Comprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease (iLBD), Helmholtz Center Munich, Neuherberg, Germany.
• Svanes C Bergen Respiratory Research Group, Institute of Medicine, University of Bergen and Department of Occupational Medicine, Haukeland University Hospital Bergen, Bergen, Norway.
• Bouzigon E Inserm U946, Genetic Variation and Human Diseases Unit, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France; Fondation Jean Dausset, Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France.
• Demenais F Inserm U946, Genetic Variation and Human Diseases Unit, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France; Fondation Jean Dausset, Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France.
• Kauffmann F Inserm U1018, CESP Centre for research in Epidemiology and Population Health, Respiratory and environmental epidemiology Team, Villejuif, France; Université Paris Sud, UMRS 1018, Villejuif, France.
• Siroux V Inserm U823, Centre de Recherche Albert Bonniot, La Tronche, France; Université Joseph Fourier, Grenoble, France.
• von Mutius E LMU Munich, University Children's Hospital, Munich, Germany.
• Ege MJ LMU Munich, University Children's Hospital, Munich, Germany.
• Braun-Fahrländer C Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
• Genuneit J Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
• Brunekreef B Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands; Centre for Prevention and Health Services Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
• Smit HA Centre for Prevention and Health Services Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
• Wijga AH Department of Epidemiology, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
• Kerkhof M Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
• Curjuric I Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
• Imboden M Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
• Thun GA Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
• Probst-Hensch N Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia.
• Freidin MB Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia.
• Bragina EIu Siberian State Medical University, Tomsk, Russia.
• Deev IA Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia; Siberian State Medical University, Tomsk, Russia.
• Puzyrev VP James Hogg iCAPTURE Center, University of British Columbia, Vancouver, British Columbia, Canada.
• Daley D James Hogg iCAPTURE Center, University of British Columbia, Vancouver, British Columbia, Canada.
• Park J Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
• Becker A Occupational and Environmental Lung Disease Unit, University of British Columbia, Vancouver, British Columbia, Canada.
• Chan-Yeung M Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta and School of Public Health, University of Alberta, Edmonton, Canada.
• Kozyrskyj AL James Hogg iCAPTURE Center, University of British Columbia, Vancouver, British Columbia, Canada.
• Pare P Pediatric Pneumology, Experimental and Clinical Research Center, Charité-Medical University, Berlin, Germany; Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
• Marenholz I Pediatric Pneumology and Immunology, Charité-Medical University, Berlin, Germany.
• Lau S Institute of Social Medicine, Epidemiology and Health Economics, Charité-Medical University, Berlin, Germany.
• Keil T Pediatric Pneumology, Experimental and Clinical Research Center, Charité-Medical University, Berlin, Germany; Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
• Lee YA Department of Paediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.
• Kabesch M Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
• Wijmenga C Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
• Franke L Department of Epidemiology, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
• Nolte IM Department of Epidemiology, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
• Vonk J Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
• Kumar A Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
• Farrall M Division of Respiratory Sciences, Imperial College, London, United Kingdom.
• Cookson WO Division of Population Health Sciences and Education, St George's, University of London, London, United Kingdom.
• Strachan DP Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
• Koppelman GH Department of Epidemiology, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: h.m.boezen@umcg.nl.
• Boezen HM

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Asthma

Female

Gene-Environment Interaction

Humans

Maternal Exposure

Microfilament Proteins

Polymorphism, Single Nucleotide

Tobacco Smoke Pollution