Journal article
RNA splicing and its connection with other regulatory layers in somatic cell reprogramming.
- Zavolan M RNA Regulatory Networks, Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland; Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland. Electronic address: mihaela.zavolan@unibas.ch.
- Kanitz A RNA Regulatory Networks, Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland; Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland.
- 2017-12-25
Published in:
- Current opinion in cell biology. - 2018
English
Understanding how cell identity is established and maintained is one of the most exciting challenges of molecular biology today. Recent work has added a conserved layer of RNA splicing and other post-transcriptional regulatory processes to the transcriptional and epigenetic networks already known to cooperate in the establishment and maintenance of cell identity. Here we summarize these findings, highlighting specifically the multitude of splicing factors that can modulate the efficiency of somatic cell reprogramming. Distinct patterns of gene expression dynamics of these factors during reprogramming suggest that further improvements in efficiency could be obtained through optimal timing of overexpression or knockdown of individual regulators.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.ceb.2017.12.002
- PMID 29275148
- Persistent URL
- https://sonar.ch/global/documents/232238
Statistics
Document views: 28
File downloads: