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Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning.

  • Kaiser M Parasite Chemotherapy, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
  • Mäser P Parasite Chemotherapy, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
  • Tadoori LP Drugs for Neglected Diseases initiative, Geneva, Switzerland.
  • Ioset JR Drugs for Neglected Diseases initiative, Geneva, Switzerland.
  • Brun R Parasite Chemotherapy, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
  • 2015-08-14
Published in:
  • PloS one. - 2015
Animals
Antiprotozoal Agents
Cells, Cultured
Chagas Disease
Disease Models, Animal
Drug Evaluation, Preclinical
Drug Repositioning
Humans
Leishmania donovani
Leishmaniasis
Macrophages, Peritoneal
Malaria
Mice
Neglected Diseases
Plasmodium falciparum
Trypanosoma brucei rhodesiense
Trypanosoma cruzi
Trypanosomiasis, African
English Neglected tropical diseases cause significant morbidity and mortality and are a source of poverty in endemic countries. Only a few drugs are available to treat diseases such as leishmaniasis, Chagas' disease, human African trypanosomiasis and malaria. Since drug development is lengthy and expensive, a drug repurposing strategy offers an attractive fast-track approach to speed up the process. A set of 100 registered drugs with drug repositioning potential for neglected diseases was assembled and tested in vitro against four protozoan parasites associated with the aforementioned diseases. Several drugs and drug classes showed in vitro activity in those screening assays. The results are critically reviewed and discussed in the perspective of a follow-up drug repositioning strategy where R&D has to be addressed with limited resources.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/232255
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