Journal article
Cancer stem cells, cancer-initiating cells and methods for their detection.
- Akbari-Birgani S Faculty of Biological Sciences, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, Iran.
- Paranjothy T Institute for Management and Innovation, University of Toronto Mississauga, Canada.
- Zuse A Department of Surgery, Hospital of Baselland, Affiliated with the Univ. Basel, Liestal, Switzerland.
- Janikowski T School of Pharmacy, Div. Lab. Med. in Sosnowiec, Dept. Mol. Biol. Med. Univ. Silesia, Poland.
- Cieślar-Pobuda A Institute of Automatic Control, Silesian Univ. of Technology, Gliwice, Poland.
- Likus W Department of Anatomy, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
- Urasińska E Department of Pathology, Pomeranian Medical University, Szczecin, Poland.
- Schweizer F Department of Chemistry, University of Manitoba, Winnipeg, Canada.
- Ghavami S Children Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Canada; Department of Human Anatomy and Cell Science, University of Manitoba, Canada; Health Policy Research Centre, Shiraz Medical University, Shiraz, Iran.
- Klonisch T Department of Human Anatomy and Cell Science, University of Manitoba, Canada.
- Łos MJ LinkoCare Life Sciences AB, 583 30 Linköping, Sweden; ENT Department, School of Medicine, Medical University of Silesia, Katowice, Poland. Electronic address: mjelos@gmail.com.
- 2016-03-16
Published in:
- Drug discovery today. - 2016
English
The cancer stem cell (CSC) hypothesis considers CSCs as the main culprits of tumor initiation, propagation, metastasis and therapy failure. CSCs represent a minority subpopulation of cells within a tumor. Their detection, characterization and monitoring are crucial steps toward a better understanding of the biological roles of these special cells in the development and propagation of tumors which, in turn, improves clinical reasoning and treatment options. Nowadays, in vitro and in vivo assays are available that address the self-renewal and differentiation potential of CSCs, and advanced in vivo molecular imaging technology facilitates the detection and provides an unprecedented in vivo observation platform to study the behavior of CSCs in their natural environment. Here, we provide a brief overview of CSCs and describe modern cellular models and labeling techniques to study and trace CSCs.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.drudis.2016.03.004
- PMID 26976692
- Persistent URL
- https://sonar.ch/global/documents/232405
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