Journal article
Heart-sparing volumetric modulated arc therapy for whole lung irradiation.
- Papachristofilou A Clinic of Radiotherapy and Radiation Oncology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland. alexandros.papachristofilou@usb.ch.
- Hottinger AL Clinic of Radiotherapy and Radiation Oncology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
- Weinhold O Clinic of Radiotherapy and Radiation Oncology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
- Avcu YK Clinic of Radiotherapy and Radiation Oncology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
- Finazzi T Clinic of Radiotherapy and Radiation Oncology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
- Diesch T Department of Pediatric Oncology and Hematology, University Children's Hospital Basel, Basel, Switzerland.
- Schratzenstaller U Clinic of Radiotherapy and Radiation Oncology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
- 2018-09-08
Published in:
- Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]. - 2019
Heart-sparing
Nephroblastoma
Organ-sparing treatments
Adolescent
Chemotherapy, Adjuvant
Combined Modality Therapy
Heart
Humans
Kidney Neoplasms
Lung Neoplasms
Male
Pneumonectomy
Radiation Injuries
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Intensity-Modulated
Wilms Tumor
English
PURPOSE
Whole lung irradiation (WLI) is indicated for subgroups of patients with lung metastases from Wilms' tumor (nephroblastoma). WLI has traditionally been performed with an anterior/posterior field arrangement with poor potential for heart sparing; thus, new techniques are desirable to achieve a lower dose to the heart.
MATERIALS AND METHODS
We utilized volumetric modulated arc therapy (VMAT) for WLI with 18 Gy in a patient with metastatic nephroblastoma. The planning results were compared against a three-dimensional (3D) conformal plan.
RESULTS
VMAT resulted in adequate target volume coverage with the prescribed dose. Mean heart dose was 10.2 Gy. The dose to organs at risk (OAR) was generally more favorable with VMAT when compared with a 3D-conformal radiotherapy plan.
DISCUSSION
WLI with VMAT provides superior sparing of OARs and especially a considerably lower dose to the heart.
Whole lung irradiation (WLI) is indicated for subgroups of patients with lung metastases from Wilms' tumor (nephroblastoma). WLI has traditionally been performed with an anterior/posterior field arrangement with poor potential for heart sparing; thus, new techniques are desirable to achieve a lower dose to the heart.
MATERIALS AND METHODS
We utilized volumetric modulated arc therapy (VMAT) for WLI with 18 Gy in a patient with metastatic nephroblastoma. The planning results were compared against a three-dimensional (3D) conformal plan.
RESULTS
VMAT resulted in adequate target volume coverage with the prescribed dose. Mean heart dose was 10.2 Gy. The dose to organs at risk (OAR) was generally more favorable with VMAT when compared with a 3D-conformal radiotherapy plan.
DISCUSSION
WLI with VMAT provides superior sparing of OARs and especially a considerably lower dose to the heart.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1007/s00066-018-1363-6
- PMID 30191284
- Persistent URL
- https://sonar.ch/global/documents/232473
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