T-bet and Eomesodermin in NK Cell Development, Maturation, and Function.
- Simonetta F Department of Medical Specialties, Division of Hematology, Geneva University Hospitals, University of Geneva , Geneva , Switzerland.
- Pradier A Department of Medical Specialties, Division of Hematology, Geneva University Hospitals, University of Geneva , Geneva , Switzerland.
- Roosnek E Department of Medical Specialties, Division of Hematology, Geneva University Hospitals, University of Geneva , Geneva , Switzerland.
- 2016-07-06
Published in:
- Frontiers in immunology. - 2016
English
Recent reports give insights into the role of the T-box transcription factors, T-bet and Eomesodermin (Eomes), in NK cell biology. In this mini-review, we recapitulate the initial reports that delineate T-bet and Eomes as master regulators of NK cell development, maturation, and function. We discuss how T-bet and Eomes expression is regulated during NK cell development and peripheral maturation. Furthermore, we summarize the current literature on the role of T-bet and Eomes in the transcriptional regulation of NK cell function and review possible effects of T-box transcription factor anomalies during aging, infection, cancer, and after hematopoietic stem cell transplantation. We discuss how the current data argue in favor of a model of T-bet and Eomes synergy in transcriptional regulation of NK cell function and identify T-box transcription factors as potential targets for therapeutic interventions.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.3389/fimmu.2016.00241
- PMID 27379101
- Persistent URL
- https://sonar.ch/global/documents/232504
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