Exposure to elemental composition of outdoor PM2.5 at birth and cognitive and psychomotor function in childhood in four European birth cohorts.
- Lubczyńska MJ ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Doctor Aiguader 88, 08003 Barcelona, Spain; Pompeu Fabra University (UPF), Doctor Aiguader, 88 08003 Barcelona, Spain; Spanish Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain. Electronic address: gosia.lubczynska@isglobal.org.
- Sunyer J ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Doctor Aiguader 88, 08003 Barcelona, Spain; Pompeu Fabra University (UPF), Doctor Aiguader, 88 08003 Barcelona, Spain; Spanish Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain. Electronic address: jordi.sunyer@isglobal.org.
- Tiemeier H Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre-Sophia Children's Hospital, Dr. Molewaterplein, 50, 3015 GE Rotterdam, The Netherlands; Department of Epidemiology, Erasmus Medical Centre, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands; Department of Psychiatry, Erasmus Medical Centre, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands. Electronic address: h.tiemeier@erasmusmc.nl.
- Porta D Department of Epidemiology, Lazio Regional Health Service, Via Cristoforo Colombo, 112 Rome, Italy. Electronic address: d.porta@deplazio.it.
- Kasper-Sonnenberg M Department of Hygiene, Social and Environmental Medicine, Ruhr-University Bochum, Universitätsstraße 150, D-44801 Bochum, Germany. Electronic address: kasper-sonnenberg@hygiene.rub.de.
- Jaddoe VWV Department of Epidemiology, Erasmus Medical Centre, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands; The Generation R Study, Erasmus Medical Centre, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands; Department of Pediatrics, Erasmus Medical Centre-Sophia Children's Hospital, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands. Electronic address: v.jaddoe@erasmusmc.nl.
- Basagaña X ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Doctor Aiguader 88, 08003 Barcelona, Spain; Pompeu Fabra University (UPF), Doctor Aiguader, 88 08003 Barcelona, Spain; Spanish Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain. Electronic address: xavier.basagana@isglobal.org.
- Dalmau-Bueno A ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Doctor Aiguader 88, 08003 Barcelona, Spain; Pompeu Fabra University (UPF), Doctor Aiguader, 88 08003 Barcelona, Spain; Spanish Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain. Electronic address: albert.dalmau@isglobal.org.
- Forastiere F Department of Epidemiology, Lazio Regional Health Service, Via Cristoforo Colombo, 112 Rome, Italy. Electronic address: f.forastiere@deplazio.it.
- Wittsiepe J Department of Hygiene, Social and Environmental Medicine, Ruhr-University Bochum, Universitätsstraße 150, D-44801 Bochum, Germany. Electronic address: wittsiepe@hygiene.ruhr-uni-bochum.de.
- Hoffmann B Heinrich-Heine University of Düsseldorf, Medical Faculty, Düsseldorf, Germany. Electronic address: b.hoffmann@uni-duesseldorf.de.
- Nieuwenhuijsen M ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Doctor Aiguader 88, 08003 Barcelona, Spain; Pompeu Fabra University (UPF), Doctor Aiguader, 88 08003 Barcelona, Spain; Spanish Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain. Electronic address: mark.nieuwenhuijsen@isglobal.org.
- Hoek G Institute for Risk Assessment Sciences, Utrecht University, Yalelaan 2, 3584 CM Utrecht, The Netherlands. Electronic address: g.hoek@uu.nl.
- de Hoogh K Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland; University of Basel, Petersplatz 1, 4001 Basel, Switzerland. Electronic address: c.dehoogh@unibas.ch.
- Brunekreef B Institute for Risk Assessment Sciences, Utrecht University, Yalelaan 2, 3584 CM Utrecht, The Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 80178, 3508 TD Utrecht, The Netherlands. Electronic address: b.brunekreef@uu.nl.
- Guxens M ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Doctor Aiguader 88, 08003 Barcelona, Spain; Pompeu Fabra University (UPF), Doctor Aiguader, 88 08003 Barcelona, Spain; Spanish Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre-Sophia Children's Hospital, Dr. Molewaterplein, 50, 3015 GE Rotterdam, The Netherlands. Electronic address: monica.guxens@isglobal.org.
- 2017-10-10
Published in:
- Environment international. - 2017
Air pollution
Child development
Child health
Neuropsychological tests
Particulate matter
Air Pollutants
Air Pollution
Child
Child, Preschool
Cognition Disorders
Cohort Studies
Environmental Exposure
Europe
Female
Humans
Infant
Male
Particulate Matter
Psychomotor Performance
English
BACKGROUND
Little is known about developmental neurotoxicity of particulate matter composition. We aimed to investigate associations between exposure to elemental composition of outdoor PM2.5 at birth and cognitive and psychomotor functions in childhood.
METHODS
We analyzed data from 4 European population-based birth cohorts in the Netherlands, Germany, Italy and Spain, with recruitment in 2000-2006. Elemental composition of PM2.5 measurements were performed in each region in 2008-2011 and land use regression models were used to predict concentrations at participants' residential addresses at birth. We selected 8 elements (copper, iron, potassium, nickel, sulfur, silicon, vanadium and zinc) and used principal component analysis to combine elements from the same sources. Cognitive (general, verbal, and non-verbal) and psychomotor (fine and gross) functions were assessed between 1 and 9years of age. Adjusted cohort-specific effect estimates were combined using random-effects meta-analysis.
RESULTS
7246 children were included in this analysis. Single element analysis resulted in negative association between estimated airborne iron and fine motor function (-1.25 points [95% CI -2.45 to -0.06] per 100ng/m3 increase of iron). Association between the motorized traffic component, derived from principal component analysis, and fine motor function was not significant (-0.29 points [95% CI -0.64 to 0.06] per unit increase). None of the elements were associated with gross motor function or cognitive function, although the latter estimates were predominantly negative.
CONCLUSION
Our results suggest that iron, a highly prevalent element in motorized traffic pollution, may be a neurotoxic compound. This raises concern given the ubiquity of motorized traffic air pollution.
Little is known about developmental neurotoxicity of particulate matter composition. We aimed to investigate associations between exposure to elemental composition of outdoor PM2.5 at birth and cognitive and psychomotor functions in childhood.
METHODS
We analyzed data from 4 European population-based birth cohorts in the Netherlands, Germany, Italy and Spain, with recruitment in 2000-2006. Elemental composition of PM2.5 measurements were performed in each region in 2008-2011 and land use regression models were used to predict concentrations at participants' residential addresses at birth. We selected 8 elements (copper, iron, potassium, nickel, sulfur, silicon, vanadium and zinc) and used principal component analysis to combine elements from the same sources. Cognitive (general, verbal, and non-verbal) and psychomotor (fine and gross) functions were assessed between 1 and 9years of age. Adjusted cohort-specific effect estimates were combined using random-effects meta-analysis.
RESULTS
7246 children were included in this analysis. Single element analysis resulted in negative association between estimated airborne iron and fine motor function (-1.25 points [95% CI -2.45 to -0.06] per 100ng/m3 increase of iron). Association between the motorized traffic component, derived from principal component analysis, and fine motor function was not significant (-0.29 points [95% CI -0.64 to 0.06] per unit increase). None of the elements were associated with gross motor function or cognitive function, although the latter estimates were predominantly negative.
CONCLUSION
Our results suggest that iron, a highly prevalent element in motorized traffic pollution, may be a neurotoxic compound. This raises concern given the ubiquity of motorized traffic air pollution.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1016/j.envint.2017.09.015
- PMID 28988795
- Persistent URL
- https://sonar.ch/global/documents/232513
Export to…
Statistics
Document views: 62
File downloads:
- Full-text: 0