Abnormalities in cortical gray matter density in borderline personality disorder.
- Rossi R Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy. Electronic address: rrossi@fatebenefratelli.it.
- Lanfredi M Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy.
- Pievani M LENITEM, Laboratory of Epidemiology, Neuroimaging, & Telemedicine, Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy.
- Boccardi M LENITEM, Laboratory of Epidemiology, Neuroimaging, & Telemedicine, Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy.
- Rasser PE Centre for translational Neuroscience and Mental Health, The University of Newcastle, New South Wales, Australia; Schizophrenia Research Institute, Darlinghurst, Australia; Hunter Medical Research Institute, Newcastle, Australia.
- Thompson PM Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA.
- Cavedo E LENITEM, Laboratory of Epidemiology, Neuroimaging, & Telemedicine, Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy; Cognition, neuroimaging and brain diseases Laboratory, Centre de Recherche de l'Insitut du Cerveau et de la Moelle (CRICM) UMRS_975, Université Pierre-et-Marie-Curie, Paris, France.
- Cotelli M Unit of Neuropsychology, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy.
- Rosini S Unit of Neuropsychology, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy.
- Beneduce R Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy.
- Bignotti S Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy.
- Magni LR Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy.
- Rillosi L Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy.
- Magnaldi S Unit of Neuroradiology, Poliambulanza Hospital, Brescia, Italy.
- Cobelli M Unit of Neuroradiology, Poliambulanza Hospital, Brescia, Italy.
- Rossi G Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy.
- Frisoni GB LENITEM, Laboratory of Epidemiology, Neuroimaging, & Telemedicine, Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy; Memory Clinic and LANVIE, Laboratory of Neuroimaging of Aging, University Hospitals, University of Geneva, Geneva, Switzerland.
- 2015-01-07
Published in:
- European psychiatry : the journal of the Association of European Psychiatrists. - 2015
Borderline personality disorder
MRI
Neuroimaging
Adult
Borderline Personality Disorder
Brain Mapping
Cerebral Cortex
Female
Frontal Lobe
Gray Matter
Gyrus Cinguli
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Prefrontal Cortex
English
BACKGROUND
Borderline personality disorder (BPD) is a chronic condition with a strong impact on patients' affective, cognitive and social functioning. Neuroimaging techniques offer invaluable tools to understand the biological substrate of the disease. We aimed to investigate gray matter alterations over the whole cortex in a group of Borderline Personality Disorder (BPD) patients compared to healthy controls (HC).
METHODS
Magnetic resonance-based cortical pattern matching was used to assess cortical gray matter density (GMD) in 26 BPD patients and in their age- and sex-matched HC (age: 38 ± 11; females: 16, 61%).
RESULTS
BPD patients showed widespread lower cortical GMD compared to HC (4% difference) with peaks of lower density located in the dorsal frontal cortex, in the orbitofrontal cortex, the anterior and posterior cingulate, the right parietal lobe, the temporal lobe (medial temporal cortex and fusiform gyrus) and in the visual cortex (P<0.005). Our BPD subjects displayed a symmetric distribution of anomalies in the dorsal aspect of the cortical mantle, but a wider involvement of the left hemisphere in the mesial aspect in terms of lower density. A few restricted regions of higher density were detected in the right hemisphere. All regions remained significant after correction for multiple comparisons via permutation testing.
CONCLUSIONS
BPD patients feature specific morphology of the cerebral structures involved in cognitive and emotional processing and social cognition/mentalization, consistent with clinical and functional data.
Borderline personality disorder (BPD) is a chronic condition with a strong impact on patients' affective, cognitive and social functioning. Neuroimaging techniques offer invaluable tools to understand the biological substrate of the disease. We aimed to investigate gray matter alterations over the whole cortex in a group of Borderline Personality Disorder (BPD) patients compared to healthy controls (HC).
METHODS
Magnetic resonance-based cortical pattern matching was used to assess cortical gray matter density (GMD) in 26 BPD patients and in their age- and sex-matched HC (age: 38 ± 11; females: 16, 61%).
RESULTS
BPD patients showed widespread lower cortical GMD compared to HC (4% difference) with peaks of lower density located in the dorsal frontal cortex, in the orbitofrontal cortex, the anterior and posterior cingulate, the right parietal lobe, the temporal lobe (medial temporal cortex and fusiform gyrus) and in the visual cortex (P<0.005). Our BPD subjects displayed a symmetric distribution of anomalies in the dorsal aspect of the cortical mantle, but a wider involvement of the left hemisphere in the mesial aspect in terms of lower density. A few restricted regions of higher density were detected in the right hemisphere. All regions remained significant after correction for multiple comparisons via permutation testing.
CONCLUSIONS
BPD patients feature specific morphology of the cerebral structures involved in cognitive and emotional processing and social cognition/mentalization, consistent with clinical and functional data.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1016/j.eurpsy.2014.11.009
- PMID 25561291
- Persistent URL
- https://sonar.ch/global/documents/232596
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