Case Report-Secondary Antibody Deficiency Due to Endogenous Hypercortisolism.
- Sarcevic J Division of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
- Cavelti-Weder C Division of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland.
- Berger CT Division of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
- Trendelenburg M Division of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
- 2020-08-01
Published in:
- Frontiers in immunology. - 2020
endogenous hypercortisolism
hypogammaglobulinemia
immune deficiency
lymphocytopenia
secondary antibody deficiency
English
Therapeutic corticosteroids have an immunosuppressive function involving several pathways, including lymphocytopenia and hypogammaglobulinemia. While these effects have been well-described in patients that received corticosteroids for therapeutic reasons, the effects of endogenous corticosteroids on the immune system are less well-understood. Here, we describe a 21-year old patient with hypercortisolism due to an ACTH producing thymic tumor. In this patient, we observed a decrease in some of the immunoglobulin classes, and in specific B and T cell populations that resembled effects caused by corticosteroid treatment. IgG levels were restored following treatment and normalization of the hypercortisolism.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.3389/fimmu.2020.01435
- PMID 32733476
- Persistent URL
- https://sonar.ch/global/documents/232619
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