Journal article
The association between smoking and risk of skin cancer: a meta-analysis of cohort studies.
- Arafa A Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita-shi, Osaka, 565-0871, Japan. ahmed011172@med.bsu.edu.eg.
- Mostafa A Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
- Navarini AA Department of Dermatology, University Hospital Basel, Basel, Switzerland.
- Dong JY Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita-shi, Osaka, 565-0871, Japan.
- 2020-05-28
Published in:
- Cancer causes & control : CCC. - 2020
Basal cell carcinoma
Malignant melanoma
Meta-analysis
Smoking
Squamous cell carcinoma
Carcinoma, Basal Cell
Carcinoma, Squamous Cell
Cohort Studies
Humans
Melanoma
Risk Factors
Skin Neoplasms
Smoking
English
PURPOSE
The association between smoking and the risk of skin cancers has been studied without reaching consistent findings. This study aims to assess this association through an updated meta-analysis of cohort studies.
METHODS
We retrieved cohort studies that investigated the temporal association between smoking and the risk of basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma (MM). Pooled relative risks (RRs) and confidence intervals (CIs) of the included articles were calculated for current, former, and heavy smoking compared with never smoking. Publication bias was detected using the Egger's regression.
RESULTS
A total of 15 studies, published between 1990 and 2018, were included. Current smoking was associated with a higher risk of SCC (pooled RR = 1.32, 95% CI 1.15, 1.52) but with a lower risk of BCC (pooled RR = 0.85, 95% CI 0.75, 0.96) and MM (pooled RR = 0.72, 95% CI 0.64, 0.82). No publication bias was detected, and no single study had a substantial impact on the pooled results. Similar results were detected for heavy smoking, while former smoking was not associated with the risk of skin cancer.
CONCLUSION
Current smoking and heavy smoking were associated with a higher risk of SCC but a decreased risk of BCC and MM, while former smoking was not associated with skin cancer risk.
The association between smoking and the risk of skin cancers has been studied without reaching consistent findings. This study aims to assess this association through an updated meta-analysis of cohort studies.
METHODS
We retrieved cohort studies that investigated the temporal association between smoking and the risk of basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma (MM). Pooled relative risks (RRs) and confidence intervals (CIs) of the included articles were calculated for current, former, and heavy smoking compared with never smoking. Publication bias was detected using the Egger's regression.
RESULTS
A total of 15 studies, published between 1990 and 2018, were included. Current smoking was associated with a higher risk of SCC (pooled RR = 1.32, 95% CI 1.15, 1.52) but with a lower risk of BCC (pooled RR = 0.85, 95% CI 0.75, 0.96) and MM (pooled RR = 0.72, 95% CI 0.64, 0.82). No publication bias was detected, and no single study had a substantial impact on the pooled results. Similar results were detected for heavy smoking, while former smoking was not associated with the risk of skin cancer.
CONCLUSION
Current smoking and heavy smoking were associated with a higher risk of SCC but a decreased risk of BCC and MM, while former smoking was not associated with skin cancer risk.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1007/s10552-020-01319-8
- PMID 32458137
- Persistent URL
- https://sonar.ch/global/documents/232666
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