Journal article
Prevalence of undiagnosed uterine leiomyosarcoma in women undergoing hysterectomy or myomectomy for benign indications.
- Lange S Department of Gynaecology and Obstetrics, eHnv, Yverdon-Les-Bains, Switzerland.
- Pluchino N Department of Gynaecology and Obstetrics, Gynaecologic Division, Geneva University Hospitals, Geneva, Switzerland.
- Fehlmann A Department of Gynaecology and Obstetrics, eHnv, Yverdon-Les-Bains, Switzerland.
- Marci R Department of Gynaecology and Obstetrics, Gynaecologic Division, Geneva University Hospitals, Geneva, Switzerland.
- Boukrid M Department of Gynaecology and Obstetrics, Gynaecologic Division, Geneva University Hospitals, Geneva, Switzerland.
- Jazia IB Department of Gynaecology and Obstetrics, Gynaecologic Division, Geneva University Hospitals, Geneva, Switzerland.
- Petignat P Department of Gynaecology and Obstetrics, Gynaecologic Division, Geneva University Hospitals, Geneva, Switzerland.
- Dubuisson J Department of Gynaecology and Obstetrics, Gynaecologic Division, Geneva University Hospitals, Geneva, Switzerland. Electronic address: Jean.Dubuisson@hcuge.ch.
- 2017-07-27
Published in:
- European journal of obstetrics, gynecology, and reproductive biology. - 2017
Hysterectomy
Leiomyoma
Leiomyosarcoma
Myomectomy
Prevalence
Adult
Female
Humans
Hysterectomy
Leiomyosarcoma
Middle Aged
Prevalence
Retrospective Studies
Uterine Myomectomy
Uterine Neoplasms
English
OBJECTIVE
To determine the prevalence of undiagnosed uterine leiomyosarcoma (LMS) in women undergoing hysterectomy or myomectomy for suspected benign leiomyomas.
STUDY DESIGN
Retrospective, single-centre, cohort study. Information for all gynaecological procedures for suspected benign leiomyomas between 1993 and 2016 was extracted from the hospital database. The prevalence of LMS was calculated by surgery type and age group.
RESULTS
The prevalence of LMS was 1.7/1000 [one in 603 women; 95% confidence interval (CI) 0.8-3.4] for all procedures combined. The prevalence of LMS was 1.1/1000 (one in 875 women; 95% CI 0.4-2.9) for all hysterectomies combined and 4.2/1000 (one in 240 women; 95% CI 1.4-12.2) for all myomectomies combined. For women aged <50years, the prevalence of LMS was 5.4/1000 (one in 187 women; 95% CI 1.8-15.6) for abdominal hysterectomies, 1.0/1000 (one in 1040 women; 95% CI 0.2-5.4) for laparoscopic hysterectomies, 5.2/1000 (one in 191 women; 95% CI 0.9-29.1) for abdominal myomectomies, 3.0/1000 (one in 332 women; 95% CI 0.5-16.9) for laparoscopic myomectomies and 8.6/1000 (one in 116 women; 95% CI 1.5-47.2) for hysteroscopic myomectomies.
CONCLUSIONS
Occult LMS is a rare malignant disease. This study found that the prevalence of LMS was higher in women undergoing myomectomy compared with women undergoing hysterectomy. The highest prevalence of LMS was found in women undergoing hysteroscopic myomectomy.
To determine the prevalence of undiagnosed uterine leiomyosarcoma (LMS) in women undergoing hysterectomy or myomectomy for suspected benign leiomyomas.
STUDY DESIGN
Retrospective, single-centre, cohort study. Information for all gynaecological procedures for suspected benign leiomyomas between 1993 and 2016 was extracted from the hospital database. The prevalence of LMS was calculated by surgery type and age group.
RESULTS
The prevalence of LMS was 1.7/1000 [one in 603 women; 95% confidence interval (CI) 0.8-3.4] for all procedures combined. The prevalence of LMS was 1.1/1000 (one in 875 women; 95% CI 0.4-2.9) for all hysterectomies combined and 4.2/1000 (one in 240 women; 95% CI 1.4-12.2) for all myomectomies combined. For women aged <50years, the prevalence of LMS was 5.4/1000 (one in 187 women; 95% CI 1.8-15.6) for abdominal hysterectomies, 1.0/1000 (one in 1040 women; 95% CI 0.2-5.4) for laparoscopic hysterectomies, 5.2/1000 (one in 191 women; 95% CI 0.9-29.1) for abdominal myomectomies, 3.0/1000 (one in 332 women; 95% CI 0.5-16.9) for laparoscopic myomectomies and 8.6/1000 (one in 116 women; 95% CI 1.5-47.2) for hysteroscopic myomectomies.
CONCLUSIONS
Occult LMS is a rare malignant disease. This study found that the prevalence of LMS was higher in women undergoing myomectomy compared with women undergoing hysterectomy. The highest prevalence of LMS was found in women undergoing hysteroscopic myomectomy.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.ejogrb.2017.06.029
- PMID 28743407
- Persistent URL
- https://sonar.ch/global/documents/232813
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