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Collective stresses drive competition between monolayers of normal and Ras-transformed cells.

  • Moitrier S Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168, 75005 Paris, France. isabelle.bonnet@curie.fr philippe.marcq@curie.fr and Sorbonne Université, 75005, Paris, France and Équipe Labellisée Ligue Contre le Cancer, France.
  • Blanch-Mercader C Université de Genève, Geneva, Switzerland.
  • Garcia S Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168, 75005 Paris, France. isabelle.bonnet@curie.fr philippe.marcq@curie.fr and Sorbonne Université, 75005, Paris, France and Équipe Labellisée Ligue Contre le Cancer, France.
  • Sliogeryte K Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168, 75005 Paris, France. isabelle.bonnet@curie.fr philippe.marcq@curie.fr and Sorbonne Université, 75005, Paris, France and Équipe Labellisée Ligue Contre le Cancer, France.
  • Martin T Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168, 75005 Paris, France. isabelle.bonnet@curie.fr philippe.marcq@curie.fr and Sorbonne Université, 75005, Paris, France and Équipe Labellisée Ligue Contre le Cancer, France.
  • Camonis J Institut Curie, PSL Research University, 75005 Paris, France and ART Group, Inserm U830, 75005 Paris, France.
  • Marcq P Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168, 75005 Paris, France. isabelle.bonnet@curie.fr philippe.marcq@curie.fr and Sorbonne Université, 75005, Paris, France.
  • Silberzan P Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168, 75005 Paris, France. isabelle.bonnet@curie.fr philippe.marcq@curie.fr and Sorbonne Université, 75005, Paris, France and Équipe Labellisée Ligue Contre le Cancer, France.
  • Bonnet I Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168, 75005 Paris, France. isabelle.bonnet@curie.fr philippe.marcq@curie.fr and Sorbonne Université, 75005, Paris, France and Équipe Labellisée Ligue Contre le Cancer, France.
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  • 2018-12-06
Published in:
  • Soft matter. - 2019
Biomechanical Phenomena
Cell Movement
Cell Transformation, Neoplastic
HEK293 Cells
Humans
Stress, Mechanical
ras Proteins
English We study the competition for space between two cell lines that differ only in the expression of the Ras oncogene. The two cell populations are initially separated and set to migrate antagonistically towards an in-between stripe of free substrate. After contact, their interface moves towards the population of normal cells. We interpret the velocity and traction force data taken before and after contact thanks to a hydrodynamic description of collectively migrating cohesive cell sheets. The kinematics of cells, before and after contact, allows us to estimate the relative material parameters for both cell lines. As predicted by the model, the transformed cell population with larger collective stresses pushes the wild type cell population.
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  • English
Open access status
green
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https://sonar.ch/global/documents/232869
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