Journal article
Multifactorial effects of hyperglycaemia, hyperinsulinemia and inflammation on bone remodelling in type 2 diabetes mellitus.
- Shahen VA Department of Physiology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Australia.
- Gerbaix M Division of Bone Diseases, Department of Internal Medicine Specialties, Geneva University Hospital & Faculty of Medicine, Geneva, Switzerland.
- Koeppenkastrop S Department of Physiology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Australia.
- Lim SF Department of Physiology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Australia.
- McFarlane KE Department of Physiology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Australia.
- Nguyen ANL Department of Physiology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Australia.
- Peng XY Department of Physiology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Australia.
- Weiss NB Department of Physiology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Australia.
- Brennan-Speranza TC Department of Physiology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Australia; School of Public Health, Faculty of Medicine and Health, The University of Sydney, Australia. Electronic address: tara.speranza@sydney.edu.au.
- 2020-05-02
Published in:
- Cytokine & growth factor reviews. - 2020
English
Bones undergo continuous cycles of bone remodelling that rely on the balance between bone formation and resorption. This balance allows the bone to adapt to changes in mechanical loads and repair microdamages. However, this balance is susceptible to upset in various conditions, leading to impaired bone remodelling and abnormal bones. This is usually indicated by abnormal bone mineral density (BMD), an indicator of bone strength. Despite this, patients with type 2 diabetes mellitus (T2DM) exhibit normal to high BMD, yet still suffer from an increased risk of fractures. The activity of the bone cells is also altered as indicated by the reduced levels of bone turnover markers in T2DM observed in the circulation. The underlying mechanisms behind these skeletal outcomes in patients with T2DM remain unclear. This review summarises recent findings regarding inflammatory cytokine factors associated with T2DM to understand the mechanisms involved and considers potential therapeutic interventions.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.cytogfr.2020.04.001
- PMID 32354674
- Persistent URL
- https://sonar.ch/global/documents/232932
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