Journal article
Diagnosis and management of hypersensitivity reactions to vaccines.
- Sarti L Allergy Unit, Department of Pediatrics, Anna Meyer Children's University Hospital , Florence, Italy.
- Lezmi G Service de Pneumologie et Allergologie Pédiatriques, Hôpital Necker-Enfants Malades , Paris, France.
- Mori F Allergy Unit, Department of Pediatrics, Anna Meyer Children's University Hospital , Florence, Italy.
- Giovannini M Allergy Unit, Department of Pediatrics, Anna Meyer Children's University Hospital , Florence, Italy.
- Caubet JC Division of Pediatric Allergy, Department of Pediatrics, University Hospitals of Geneva , Geneva, Switzerland.
- 2020-08-26
Published in:
- Expert review of clinical immunology. - 2020
Vaccine
egg allergy
gelatin
hypersensitivity
hypersensitivity reactions
local reactions
systemic reactions
vaccine allergy
English
INTRODUCTION
Many countries in Europe now recommend and enforce mandatory vaccinations to improve vaccination coverage. Thus, the number of adverse events following immunization (AEFI) may show an increase. Among these events, severe hypersensitivity reactions to vaccines are rare. However, it is important that they be identified and recognized so that they may be adequately managed.
AREAS COVERED
The literature search was undertaken through PubMed and Embase to identify English-language papers focusing on hypersensitivity to vaccines.
EXPERT OPINION
Hypersensitivity reactions following vaccinations are rare and are classified according to their chronology and extension: immediate when they occur within the first 4 hours following administration and non-immediate when they occur later. Local reactions are the most common adverse event following injection of vaccines and generally do not require any allergy workup. Immediate reactions, however, are potentially IgE-mediated and require an allergy workup. In general, a previously known food allergy (i.e., egg or milk) is not a contraindication to immunizations. Patients with a known allergy to gelatin, yeast, latex, antibiotics, or other specific components of vaccines require an allergy workup before administration of the vaccine.
Many countries in Europe now recommend and enforce mandatory vaccinations to improve vaccination coverage. Thus, the number of adverse events following immunization (AEFI) may show an increase. Among these events, severe hypersensitivity reactions to vaccines are rare. However, it is important that they be identified and recognized so that they may be adequately managed.
AREAS COVERED
The literature search was undertaken through PubMed and Embase to identify English-language papers focusing on hypersensitivity to vaccines.
EXPERT OPINION
Hypersensitivity reactions following vaccinations are rare and are classified according to their chronology and extension: immediate when they occur within the first 4 hours following administration and non-immediate when they occur later. Local reactions are the most common adverse event following injection of vaccines and generally do not require any allergy workup. Immediate reactions, however, are potentially IgE-mediated and require an allergy workup. In general, a previously known food allergy (i.e., egg or milk) is not a contraindication to immunizations. Patients with a known allergy to gelatin, yeast, latex, antibiotics, or other specific components of vaccines require an allergy workup before administration of the vaccine.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1080/1744666X.2020.1814745
- PMID 32838592
- Persistent URL
- https://sonar.ch/global/documents/233002
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