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Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0.

  • Percie du Sert N NC3Rs, London, United Kingdom.
  • Ahluwalia A The William Harvey Research Institute, London, United Kingdom.
  • Alam S Taylor & Francis Group, London, United Kingdom.
  • Avey MT Health Science Practice, ICF, Durham, North Carolina, United States of America.
  • Baker M Nature, San Francisco, California, United States of America.
  • Browne WJ School of Education, University of Bristol, Bristol, United Kingdom.
  • Clark A PLOS ONE, Cambridge, United Kingdom.
  • Cuthill IC School of Biological Sciences, University of Bristol, Bristol, United Kingdom.
  • Dirnagl U QUEST Center for Transforming Biomedical Research, Berlin Institute of Health & Department of Experimental Neurology, Charite Universitätsmedizin Berlin, Berlin, Germany.
  • Emerson M National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Garner P Centre for Evidence Synthesis in Global Health, Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
  • Holgate ST Clinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom.
  • Howells DW Tasmanian School of Medicine, University of Tasmania, Hobart, Australia.
  • Hurst V NC3Rs, London, United Kingdom.
  • Karp NA Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.
  • Lazic SE Prioris.ai Inc, Ottawa, Canada.
  • Lidster K NC3Rs, London, United Kingdom.
  • MacCallum CJ Hindawi Ltd, London, United Kingdom.
  • Macleod M Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
  • Pearl EJ NC3Rs, London, United Kingdom.
  • Petersen OH Academia Europaea Knowledge Hub, Cardiff University, Cardiff, United Kingdom.
  • Rawle F Medical Research Council, London, United Kingdom.
  • Reynolds P Statistics in Anesthesiology Research (STAR) Core, Department of Anesthesiology, College of Medicine, University of Florida, Gainesville, Florida, United States of America.
  • Rooney K Discipline of Exercise and Sport Science, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
  • Sena ES Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
  • Silberberg SD National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America.
  • Steckler T Janssen Pharmaceutica NV, Beerse, Belgium.
  • Würbel H Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
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  • 2020-07-15
Published in:
  • PLoS biology. - 2020
Animal Experimentation
Animal Husbandry
Animals
Confidence Intervals
Guidelines as Topic
Housing, Animal
Outcome Assessment, Health Care
Publications
Random Allocation
Reproducibility of Results
Research Report
Sample Size
English Improving the reproducibility of biomedical research is a major challenge. Transparent and accurate reporting is vital to this process; it allows readers to assess the reliability of the findings and repeat or build upon the work of other researchers. The ARRIVE guidelines (Animal Research: Reporting In Vivo Experiments) were developed in 2010 to help authors and journals identify the minimum information necessary to report in publications describing in vivo experiments. Despite widespread endorsement by the scientific community, the impact of ARRIVE on the transparency of reporting in animal research publications has been limited. We have revised the ARRIVE guidelines to update them and facilitate their use in practice. The revised guidelines are published alongside this paper. This explanation and elaboration document was developed as part of the revision. It provides further information about each of the 21 items in ARRIVE 2.0, including the rationale and supporting evidence for their inclusion in the guidelines, elaboration of details to report, and examples of good reporting from the published literature. This document also covers advice and best practice in the design and conduct of animal studies to support researchers in improving standards from the start of the experimental design process through to publication.
Language
  • English
Open access status
gold
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Persistent URL
https://sonar.ch/global/documents/233866
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