Back
Full-text
Journal article

Untangling "NETosis" from NETs.

  • Yousefi S Institute of Pharmacology, University of Bern, Bern, Switzerland.
  • Stojkov D Institute of Pharmacology, University of Bern, Bern, Switzerland.
  • Germic N Institute of Pharmacology, University of Bern, Bern, Switzerland.
  • Simon D Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Wang X Institute of Pharmacology, University of Bern, Bern, Switzerland.
  • Benarafa C Institute of Virology and Immunology, Mittelhäusern, Switzerland.
  • Simon HU Institute of Pharmacology, University of Bern, Bern, Switzerland.
Show more…
  • 2019-01-11
Published in:
  • European journal of immunology. - 2019
Cell death
Innate immunity
Mitochondrial DNA
NET formation
Neutrophils
Cell Death
Extracellular Traps
Humans
Necrosis
Neutrophil Activation
Neutrophils
English Neutrophil extracellular trap (NET) formation is a cellular function of neutrophils that facilitates the immobilization and killing of invading microorganisms in the extracellular milieu. To form NETs, neutrophils release a DNA scaffold consisting of mitochondrial DNA binding granule proteins. This process does not depend on cell death, but requires glycolytic ATP production for rearrangements in the microtubule network and F-actin. Such cytoskeletal rearrangements are essential for both mitochondrial DNA release and degranulation. However, the formation of NETs has also been described as a distinct form of programed, necrotic cell death, a process designated "NETosis." Necrotic cell death of neutrophils is associated with the permeabilization of both plasma and nuclear membranes resulting in a kind of extracellular cloud of nuclear DNA. The molecular mechanisms eliciting necrotic neutrophil death have been investigated and appear to be different from those responsible for NET formation following mitochondrial DNA release. Here, we discriminate between the mechanisms responsible for the release of mitochondrial versus nuclear DNA and address their respective functions. Our aim is to clarify existing differences of opinion in the fields of NET formation and neutrophil death.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://sonar.ch/global/documents/234529
Statistics
Document views: 61 File downloads:
  • Full-text: 0