Mobility experiments with microrobots for minimally invasive intraocular surgery.
- Ullrich F Institute of Robotics and Intelligent Systems, ETH Zurich, Zurich, Switzerland.
- Bergeles C
- Pokki J
- Ergeneman O
- Erni S
- Chatzipirpiridis G
- Pané S
- Framme C
- Nelson BJ
- 2013-03-23
Published in:
- Investigative ophthalmology & visual science. - 2013
Animals
Device Removal
Equipment Design
Eye Diseases
Female
Humans
Intraocular Pressure
Intravitreal Injections
Magnetics
Magnets
Microsurgery
Minimally Invasive Surgical Procedures
Models, Animal
Ophthalmologic Surgical Procedures
Rabbits
Robotics
Swine
Vitreous Body
Wireless Technology
English
PURPOSE
To investigate microrobots as an assistive tool for minimally invasive intraocular surgery and to demonstrate mobility and controllability inside the living rabbit eye.
METHODS
A system for wireless magnetic control of untethered microrobots was developed. Mobility and controllability of a microrobot are examined in different media, specifically vitreous, balanced salt solution (BSS), and silicone oil. This is demonstrated through ex vivo and in vivo animal experiments.
RESULTS
The developed electromagnetic system enables precise control of magnetic microrobots over a workspace that covers the posterior eye segment. The system allows for rotation and translation of the microrobot in different media (vitreous, BSS, silicone oil) inside the eye.
CONCLUSIONS
Intravitreal introduction of untethered mobile microrobots can enable sutureless and precise ophthalmic procedures. Ex vivo and in vivo experiments demonstrate that microrobots can be manipulated inside the eye. Potential applications are targeted drug delivery for maculopathies such as AMD, intravenous deployment of anticoagulation agents for retinal vein occlusion (RVO), and mechanical applications, such as manipulation of epiretinal membrane peeling (ERM). The technology has the potential to reduce the invasiveness of ophthalmic surgery and assist in the treatment of a variety of ophthalmic diseases.
To investigate microrobots as an assistive tool for minimally invasive intraocular surgery and to demonstrate mobility and controllability inside the living rabbit eye.
METHODS
A system for wireless magnetic control of untethered microrobots was developed. Mobility and controllability of a microrobot are examined in different media, specifically vitreous, balanced salt solution (BSS), and silicone oil. This is demonstrated through ex vivo and in vivo animal experiments.
RESULTS
The developed electromagnetic system enables precise control of magnetic microrobots over a workspace that covers the posterior eye segment. The system allows for rotation and translation of the microrobot in different media (vitreous, BSS, silicone oil) inside the eye.
CONCLUSIONS
Intravitreal introduction of untethered mobile microrobots can enable sutureless and precise ophthalmic procedures. Ex vivo and in vivo experiments demonstrate that microrobots can be manipulated inside the eye. Potential applications are targeted drug delivery for maculopathies such as AMD, intravenous deployment of anticoagulation agents for retinal vein occlusion (RVO), and mechanical applications, such as manipulation of epiretinal membrane peeling (ERM). The technology has the potential to reduce the invasiveness of ophthalmic surgery and assist in the treatment of a variety of ophthalmic diseases.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1167/iovs.13-11825
- PMID 23518764
- Persistent URL
- https://sonar.ch/global/documents/234583
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