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Structural and functional footprint of visual snow syndrome.

  • Schankin CJ Department of Neurology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
  • Maniyar FH Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • Chou DE Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • Eller M Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • Sprenger T Department of Neurology, DKD HELIOS Klinik Wiesbaden, Wiesbaden, Germany.
  • Goadsby PJ Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
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  • 2020-03-27
Published in:
  • Brain : a journal of neurology. - 2020
FDG PET
migraine
non-visual symptoms
visual snow
voxel-based morphometry
Adult
Brain
Case-Control Studies
Female
Humans
Male
Neuroimaging
Positron-Emission Tomography
Prospective Studies
Syndrome
Vision Disorders
Young Adult
English Patients with visual snow syndrome suffer from a continuous pan-field visual disturbance, additional visual symptoms, tinnitus, and non-perceptional symptoms. The pathophysiology of visual symptoms might involve dysfunctional visual cortex. So far, the extra-visual system has not been investigated. We aimed at identifying structural and functional correlates for visual and non-visual symptoms in visual snow syndrome. Patients were compared to age- and sex-matched controls using 18F-2-fluoro-2-deoxy-d-glucose PET (n = 20 per group) and voxel-based morphometry (n = 17 per group). Guided by the PET results, region of interest analysis was done in voxel-based morphometry to identify structural-functional correspondence. Grey matter volume was assessed globally. Patients had corresponding hypermetabolism and cortical volume increase in the extrastriate visual cortex at the junction of the right lingual and fusiform gyrus. There was hypometabolism in the right superior temporal gyrus and the left inferior parietal lobule. Patients had grey matter volume increases in the temporal and limbic lobes and decrease in the superior temporal gyrus. The corresponding structural and functional alterations emphasize the relevance of the visual association cortex for visual snow syndrome. The broad structural and functional footprint, however, confirms the clinical impression that the disorder extends beyond the visual system.
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  • English
Open access status
hybrid
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https://sonar.ch/global/documents/234783
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