Journal article
Fatigue - a symptom in endometriosis.
- Ramin-Wright A University Hospital Zurich, Dept of Reproductive Endocrinology, Frauenklinikstrasse 10, Zurich, Switzerland.
- Schwartz ASK University Hospital Zurich, Dept of Reproductive Endocrinology, Frauenklinikstrasse 10, Zurich, Switzerland.
- Geraedts K University Hospital Zurich, Dept of Reproductive Endocrinology, Frauenklinikstrasse 10, Zurich, Switzerland.
- Rauchfuss M Charité Berlin, Dept of Psychosomatics, Sauerbruchweg 5, Berlin, Germany.
- Wölfler MM University Hospital Graz, Dept of Gynecology and Obstetrics, Auenbruggerplatz 1, Graz, Austria.
- Haeberlin F Canton Hospital St. Gallen, Dept of Gynecology and Obstetrics, St. Gallen, Rorschacherstrasse 501, St. Gallen, Switzerland.
- von Orelli S Triemli Hospital Zurich, Dept of Gynecology and Obstetrics, Birmesdorferstrasse 497, Zurich, Switzerland.
- Eberhard M Canton Hospital Schaffhausen, Dept of Gynecology and Obstetrics, Geissbergstrasse 81, Schaffhausen, Switzerland.
- Imthurn B University Hospital Zurich, Dept of Reproductive Endocrinology, Frauenklinikstrasse 10, Zurich, Switzerland.
- Imesch P University Hospital Zurich, Dept of Gynecology, Frauenklinikstrasse 10, Zurich, Switzerland.
- Fink D University Hospital Zurich, Dept of Gynecology, Frauenklinikstrasse 10, Zurich, Switzerland.
- Leeners B University Hospital Zurich, Dept of Reproductive Endocrinology, Frauenklinikstrasse 10, Zurich, Switzerland.
- 2018-06-28
Published in:
- Human reproduction (Oxford, England). - 2018
depression
endometriosis
fatigue
insomnia
pain
Austria
Case-Control Studies
Cross-Sectional Studies
Endometriosis
Fatigue
Female
Germany
Health Status
Humans
Mental Health
Prevalence
Quality of Life
Risk Assessment
Risk Factors
Switzerland
English
STUDY QUESTION
Is fatigue a frequent symptom of endometriosis?
SUMMARY ANSWER
Fatigue is an underestimated symptom of endometriosis as it affects the majority of women with endometriosis, but it is not widely discussed in literature.
WHAT IS KNOWN ALREADY
Fatigue can be a symptom of endometriosis causing major distress impacting the daily activities and quality of life of women with endometriosis. However, few studies with large sample sizes have investigated fatigue as a symptom of endometriosis.
STUDY DESIGN, SIZE, DURATION
The study was designed as a multi-center matched case-control study. Recruitment took place at hospitals and private practices in Switzerland, Germany and Austria between 2010 and 2016. Data was collected from 1120 women, 560 of them with endometriosis. The women with endometriosis were matched to 560 control women in regard to age ±3 years and ethnic background.
PARTICIPANTS/MATERIALS, SETTING, METHODS
Diagnosis of women with endometriosis had to be surgically and histologically confirmed. Surgical exclusion or absence of any endometriosis-identifying symptoms was required for control subjects. Materials included surgical and histological reports as well as data retrieved from a self-administered questionnaire. This study focused on the symptom fatigue in endometriosis. Relationships of variables were established by regression analysis and associations were quantified as odds ratios.
MAIN RESULTS AND THE ROLE OF CHANCE
Frequent fatigue was experienced by a majority of women diagnosed with endometriosis (50.7% versus 22.4% in control women, P < 0.001). Fatigue in endometriosis was associated with insomnia (OR: 7.31, CI: 4.62-11.56, P < 0.001), depression (OR: 4.45, CI: 2.76-7.19, P < 0.001), pain (OR: 2.22, CI: 1.52-3.23, P < 0.001), and occupational stress (OR: 1.45, CI: 1.02-2.07, P = 0.037), but was independent of age, time since first diagnosis and stage of the disease.
LIMITATIONS, REASONS FOR CAUTION
Women with asymptomatic endometriosis cannot be excluded in the control group which would lead to underestimation of our results. The study's design allows no evaluation of causal effects.
WIDER IMPLICATIONS OF THE FINDINGS
As fatigue is experienced by numerous women with endometriosis, it needs to be addressed in the discussion of management and treatment of the disease. In addition to treating endometriosis, it would be beneficial to reduce insomnia, depression, pain and occupational stress in order to better manage fatigue.
STUDY FUNDING/COMPETING INTEREST(S)
There was no additional funding received for this study and no conflict of interest.
TRIAL REGISTRATION NUMBER
ClinicalTrials.gov, NCT02511626.
Is fatigue a frequent symptom of endometriosis?
SUMMARY ANSWER
Fatigue is an underestimated symptom of endometriosis as it affects the majority of women with endometriosis, but it is not widely discussed in literature.
WHAT IS KNOWN ALREADY
Fatigue can be a symptom of endometriosis causing major distress impacting the daily activities and quality of life of women with endometriosis. However, few studies with large sample sizes have investigated fatigue as a symptom of endometriosis.
STUDY DESIGN, SIZE, DURATION
The study was designed as a multi-center matched case-control study. Recruitment took place at hospitals and private practices in Switzerland, Germany and Austria between 2010 and 2016. Data was collected from 1120 women, 560 of them with endometriosis. The women with endometriosis were matched to 560 control women in regard to age ±3 years and ethnic background.
PARTICIPANTS/MATERIALS, SETTING, METHODS
Diagnosis of women with endometriosis had to be surgically and histologically confirmed. Surgical exclusion or absence of any endometriosis-identifying symptoms was required for control subjects. Materials included surgical and histological reports as well as data retrieved from a self-administered questionnaire. This study focused on the symptom fatigue in endometriosis. Relationships of variables were established by regression analysis and associations were quantified as odds ratios.
MAIN RESULTS AND THE ROLE OF CHANCE
Frequent fatigue was experienced by a majority of women diagnosed with endometriosis (50.7% versus 22.4% in control women, P < 0.001). Fatigue in endometriosis was associated with insomnia (OR: 7.31, CI: 4.62-11.56, P < 0.001), depression (OR: 4.45, CI: 2.76-7.19, P < 0.001), pain (OR: 2.22, CI: 1.52-3.23, P < 0.001), and occupational stress (OR: 1.45, CI: 1.02-2.07, P = 0.037), but was independent of age, time since first diagnosis and stage of the disease.
LIMITATIONS, REASONS FOR CAUTION
Women with asymptomatic endometriosis cannot be excluded in the control group which would lead to underestimation of our results. The study's design allows no evaluation of causal effects.
WIDER IMPLICATIONS OF THE FINDINGS
As fatigue is experienced by numerous women with endometriosis, it needs to be addressed in the discussion of management and treatment of the disease. In addition to treating endometriosis, it would be beneficial to reduce insomnia, depression, pain and occupational stress in order to better manage fatigue.
STUDY FUNDING/COMPETING INTEREST(S)
There was no additional funding received for this study and no conflict of interest.
TRIAL REGISTRATION NUMBER
ClinicalTrials.gov, NCT02511626.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1093/humrep/dey115
- PMID 29947766
- Persistent URL
- https://sonar.ch/global/documents/235653
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