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Can viral envelope proteins act as or induce proton channels?
Journal article

Can viral envelope proteins act as or induce proton channels?

  • 1987-10-01
Published in:
  • Bioscience reports. - 1987
Aedes
Animals
Cell Fusion
Cytopathogenic Effect, Viral
Hydrogen-Ion Concentration
Ion Channels
Protons
Viral Envelope Proteins
Viral Fusion Proteins
English The mechanism of the process leading to cell-cell fusion induced by enveloped viruses at a mildly acidic pH is as yet unknown. In this report we demonstrate that the fusion events induced by three viruses of different families, namely Semliki Forest (togavirus), vesicular stomatitis (rhabdovirus) and influenza (orthomyxovirus), share common features. In all three systems a sudden drop of the intracellular pH--below the critical extracellular pH required to trigger "fusion from within" (FFWI)--is observed. This influx of protons is specific and not due to a general leakiness of the plasma membrane, and therefore might be caused by the opening of a proton channel.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/235721
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