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Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care.

  • Breiteneder H Institute of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
  • Diamant Z Department of Respiratory Medicine & Allergology, Institute for Clinical Science, Skane University Hospital, Lund University, Lund, Sweden.
  • Eiwegger T Division of Immunology and Allergy, Food Allergy and Anaphylaxis Program, The Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Fokkens WJ Department of Otorhinolaryngology, Amsterdam University Medical Centres, Location AMC, Amsterdam, The Netherlands.
  • Traidl-Hoffmann C Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum München, Augsburg, Germany.
  • Nadeau K Sean N. Parker Center for Allergy & Asthma Research, Stanford University, Stanford, California.
  • O'Hehir RE Department of Respiratory Medicine, Allergy and Clinical Immunology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
  • O'Mahony L Departments of Medicine and Microbiology, APC Microbiome Ireland, National University of Ireland, Cork, Ireland.
  • Pfaar O Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
  • Torres MJ Allergy Unit, Regional University Hospital of Malaga, IBIMA-UMA-ARADyAL, Malaga, Spain.
  • Wang Y Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Zhang L Department of Otolaryngology Head and Neck Surgery and Department of Allergy, Beijing Tongren Hospital, Beijing, China.
  • Akdis CA Christine Kühne Center for Allergy Research and Education, Davos, Switzerland.
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  • 2019-05-07
Published in:
  • Allergy. - 2019
allergy
exposome
microbiome
neuroimmune
respiratory viral infections
Allergens
Disease Susceptibility
Environment
Environmental Exposure
Health Services Needs and Demand
Host-Pathogen Interactions
Humans
Hypersensitivity
Immune Tolerance
Immunomodulation
Inflammation
Neuroimmunomodulation
Patient Care
Precision Medicine
Quality Improvement
Research
English The specialties of allergy and clinical immunology have entered the era of precision medicine with the stratification of diseases into distinct disease subsets, specific diagnoses, and targeted treatment options, including biologicals and small molecules. This article reviews recent developments in research and patient care and future trends in the discipline. The section on basic mechanisms of allergic diseases summarizes the current status and defines research needs in structural biology, type 2 inflammation, immune tolerance, neuroimmune mechanisms, role of the microbiome and diet, environmental factors, and respiratory viral infections. In the section on diagnostic challenges, clinical trials, precision medicine and immune monitoring of allergic diseases, asthma, allergic and nonallergic rhinitis, and new approaches to the diagnosis and treatment of drug hypersensitivity reactions are discussed in further detail. In the third section, unmet needs and future research areas for the treatment of allergic diseases are highlighted with topics on food allergy, biologics, small molecules, and novel therapeutic concepts in allergen-specific immunotherapy for airway disease. Unknowns and future research needs are discussed at the end of each subsection.
Language
  • English
Open access status
hybrid
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https://sonar.ch/global/documents/235959
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