Hypoxia Is Present in Murine Atherosclerotic Plaques and Has Multiple Adverse Effects on Macrophage Lipid Metabolism

Parathath, Sajesh; Mick, Stephanie L.; Feig, Jonathan E.; Joaquin, Victor; Grauer, Lisa; Habiel, David M.; Gassmann, Max; Gardner, Lawrence B.; Fisher, Edward A.

doi:10.1161/circresaha.111.246363

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Hypoxia Is Present in Murine Atherosclerotic Plaques and Has Multiple Adverse Effects on Macrophage Lipid Metabolism

Parathath, Sajesh From the NYU School of Medicine, Departments of Medicine (Cardiology) and Cell Biology, Marc and Ruti Bell Program in Vascular Biology, New York, NY (S.P., S.L.M., J.E.F., V.J., L.G., D.M.H., E.A.F.); the Institute of Veterinary Physiology, Vetsuisse Faculty, and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland (M.G.); NYU School of Medicine, Department of Medicine (Hematology), New York, NY (L.B.G.); and the Departments of Cardiovascular Medicine and...
Mick, Stephanie L. From the NYU School of Medicine, Departments of Medicine (Cardiology) and Cell Biology, Marc and Ruti Bell Program in Vascular Biology, New York, NY (S.P., S.L.M., J.E.F., V.J., L.G., D.M.H., E.A.F.); the Institute of Veterinary Physiology, Vetsuisse Faculty, and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland (M.G.); NYU School of Medicine, Department of Medicine (Hematology), New York, NY (L.B.G.); and the Departments of Cardiovascular Medicine and...
Feig, Jonathan E. From the NYU School of Medicine, Departments of Medicine (Cardiology) and Cell Biology, Marc and Ruti Bell Program in Vascular Biology, New York, NY (S.P., S.L.M., J.E.F., V.J., L.G., D.M.H., E.A.F.); the Institute of Veterinary Physiology, Vetsuisse Faculty, and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland (M.G.); NYU School of Medicine, Department of Medicine (Hematology), New York, NY (L.B.G.); and the Departments of Cardiovascular Medicine and...
Joaquin, Victor From the NYU School of Medicine, Departments of Medicine (Cardiology) and Cell Biology, Marc and Ruti Bell Program in Vascular Biology, New York, NY (S.P., S.L.M., J.E.F., V.J., L.G., D.M.H., E.A.F.); the Institute of Veterinary Physiology, Vetsuisse Faculty, and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland (M.G.); NYU School of Medicine, Department of Medicine (Hematology), New York, NY (L.B.G.); and the Departments of Cardiovascular Medicine and...
Grauer, Lisa From the NYU School of Medicine, Departments of Medicine (Cardiology) and Cell Biology, Marc and Ruti Bell Program in Vascular Biology, New York, NY (S.P., S.L.M., J.E.F., V.J., L.G., D.M.H., E.A.F.); the Institute of Veterinary Physiology, Vetsuisse Faculty, and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland (M.G.); NYU School of Medicine, Department of Medicine (Hematology), New York, NY (L.B.G.); and the Departments of Cardiovascular Medicine and...
Habiel, David M. From the NYU School of Medicine, Departments of Medicine (Cardiology) and Cell Biology, Marc and Ruti Bell Program in Vascular Biology, New York, NY (S.P., S.L.M., J.E.F., V.J., L.G., D.M.H., E.A.F.); the Institute of Veterinary Physiology, Vetsuisse Faculty, and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland (M.G.); NYU School of Medicine, Department of Medicine (Hematology), New York, NY (L.B.G.); and the Departments of Cardiovascular Medicine and...
Gassmann, Max From the NYU School of Medicine, Departments of Medicine (Cardiology) and Cell Biology, Marc and Ruti Bell Program in Vascular Biology, New York, NY (S.P., S.L.M., J.E.F., V.J., L.G., D.M.H., E.A.F.); the Institute of Veterinary Physiology, Vetsuisse Faculty, and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland (M.G.); NYU School of Medicine, Department of Medicine (Hematology), New York, NY (L.B.G.); and the Departments of Cardiovascular Medicine and...
Gardner, Lawrence B. From the NYU School of Medicine, Departments of Medicine (Cardiology) and Cell Biology, Marc and Ruti Bell Program in Vascular Biology, New York, NY (S.P., S.L.M., J.E.F., V.J., L.G., D.M.H., E.A.F.); the Institute of Veterinary Physiology, Vetsuisse Faculty, and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland (M.G.); NYU School of Medicine, Department of Medicine (Hematology), New York, NY (L.B.G.); and the Departments of Cardiovascular Medicine and...
Fisher, Edward A. From the NYU School of Medicine, Departments of Medicine (Cardiology) and Cell Biology, Marc and Ruti Bell Program in Vascular Biology, New York, NY (S.P., S.L.M., J.E.F., V.J., L.G., D.M.H., E.A.F.); the Institute of Veterinary Physiology, Vetsuisse Faculty, and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland (M.G.); NYU School of Medicine, Department of Medicine (Hematology), New York, NY (L.B.G.); and the Departments of Cardiovascular Medicine and...