To split or to lump? Classifying the central disorders of hypersomnolence.
- Fronczek R Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
- Arnulf I Sorbonne University, National Reference Center for Rare Hypersomnia, Pitie-Salpetriere Hospital, Paris, France.
- Baumann CR Department of Neurology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
- Maski K Department of Neurology, Harvard Medical School, Boston Children's Hospital, Boston, MA.
- Pizza F Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
- Trotti LM Department of Neurology, Emory University School of Medicine, Atlanta, GA.
- 2020-03-21
Published in:
- Sleep. - 2020
English
The classification of the central disorders of hypersomnolence has undergone multiple iterations in an attempt to capture biologically meaningful disease entities in the absence of known pathophysiology. Accumulating data suggests that further refinements may be necessary. At the 7th International Symposium on Narcolepsy, a group of clinician-scientists evaluated data in support of keeping or changing classifications, and as a result suggest several changes. First, idiopathic hypersomnia with long sleep durations appears to be an identifiable and meaningful disease subtype. Second, idiopathic hypersomnia without long sleep time and narcolepsy without cataplexy share substantial phenotypic overlap and cannot reliably be distinguished with current testing, and so combining them into a single disease entity seems warranted at present. Moving forward, it is critical to phenotype patients across a wide variety of clinical and biological features, to aid in future refinements of disease classification.
- Language
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- English
- Open access status
- hybrid
- Identifiers
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- DOI 10.1093/sleep/zsaa044
- PMID 32193539
- Persistent URL
- https://sonar.ch/global/documents/236133
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